- ►diabetesjournals.org P Achenbach, E Bonifacio, K Koczwara, AG Ziegler - Diabetes, 2005 - Am Diabetes Assoc The natural history of autoimmune type 1 diabetes in children is associated with the appearance
of islet autoantibodies early in life, which is influenced by genetic and environmental factors.
Once islet autoantibodies have developed, the progression to diabetes in ... Cited by 37 - Related articles - BL Direct - All 9 versions
P Achenbach, E Bonifacio, AG Ziegler - Current Diabetes Reports, 2005 - Springer Introduction Accurate estimation of the risk for developing type 1 diabetes mellitus (T1DM) is
important for the identification of indi- viduals who may benefit from inclusion in interventional
trials aiming to prevent the onset of disease. Intervention trials will largely depend on a ... Cited by 17 - Related articles - All 2 versions
- ►annals.org [PDF] M Hummel, E Bonifacio, S Schmid, M Walter … - Annals of internal …, 2004 - Am Coll Physicians Brief Communication: Early Appearance of Islet Autoantibodies ... Predicts Childhood Type 1
Diabetes in Offspring of Diabetic Parents ... Michael Hummel, MD; Ezio Bonifacio, PhD; Sandra
Schmid, PhD; Markus Walter, MD; Annette Knopff; and Anette-G. Ziegler, MD Cited by 39 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org C Pihoker, LK Gilliam, CS Hampe, Å Lernmark - Diabetes, 2005 - Am Diabetes Assoc Islet cell autoantibodies are strongly associated with the development of type 1 diabetes. The
appearance of autoantibodies to one or several of the autoantigens—GAD65, IA-2, or
insulin—signals an autoimmune pathogenesis of β-cell killing. A β-cell attack may be best ... Cited by 53 - Related articles - BL Direct - All 6 versions
P Achenbach, K Warncke, J Reiter, HE Naserke, AJK … - Diabetes, 2004 - Am Diabetes Assoc Family history of type 1 diabetes and autoantibodies to the islet antigens insulin (IAA), glutamate
decarboxylase (GADA), and the protein tyrosine phosphatase-like protein IA-2 (IA-2A) are strong
predictors of type 1 diabetes, but the rate of progression to diabetes in multiple islet ... Cited by 91 - Related articles - BL Direct - All 6 versions
S Schmid, D Buuck, A Knopff, E Bonifacio, AG Ziegler - Diabetologia, 2004 - Springer To the Editor: The early introduction of foods containing glu- ten or cereal before the age of 3
months is associated with an increased risk of islet autoimmunity in childhood [1, 2]. A pilot study
called BABYDIET is currently underway to deter- mine whether primary intervention ... Cited by 16 - Related articles - BL Direct - All 4 versions
N Lammi, M Karvonen, J Tuomilehto - Medical science monitor: …, 2005 - ncbi.nlm.nih.gov Type 1 diabetes mellitus (T1DM) results from environmental factors acting on genetically susceptible
individuals. Microbial infections and their immunological consequences are suspected to take
part in the pathogenesis of T1DM. Congenital rubella infection has been strongly ... Cited by 19 - Related articles - All 6 versions
P Achenbach, AG Ziegler - Best Practice & Research Clinical Endocrinology & …, 2005 - Elsevier Type 1 diabetes mellitus is preceded by autoimmunity against the insulin-producing islet β
cells. Autoantibodies against islet antigens such as insulin, glutamic acid decarboxylase, and
the protein tyrosine phosphatase-like molecule IA-2 are found in most patients with type 1 ... Cited by 4 - Related articles - All 13 versions
- ►nih.gov P Achenbach, K Koczwara, A Knopff, H … - Journal of Clinical …, 2004 - Am Soc Clin Investig Children at risk for type 1 diabetes can develop early insulin autoantibodies (IAAs). Many, but
not all, of these children subsequently develop multiple islet autoantibodies and diabetes. To
determine whether disease progression is reflected by autoantibody maturity, IAA affinity ... Cited by 66 - Related articles - BL Direct - All 10 versions
P Achenbach, AG Ziegler - … in Childhood and Adolescence: 40 Tables, 2005 - books.google.com 4 6 Age (years) Fig. 1. Life-table islet autoantibody frequencies for IAA, GADA, and IA-2A in offspring
of parents with type 1 diabetes. Autoantibody-positive events correspond to samples taken at
approximately 9 months and 2, 5 and 8 years of age. Adapted from Hummel et al.[57]. ... Related articles - All 4 versions
