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Scholar Results 1 - 10 of about 101 related to Kubosaki: Dense Core Vesicle Proteins IA-2 and IA-2β. (0.10 sec) 

Dense Core Vesicle Proteins IA-2 and IA-2β


A Kubosaki, S Nakamura, AL Notkins - Diabetes, 2005 - Am Diabetes Assoc
IA-2 and IA-2β are members of the transmembrane protein tyrosine phosphatase
family located in dense core vesicles of neuroendocrine cells, including the
β-cells of pancreatic islets. In the present study, by mating C57BL/6Nci ...
Cited by 12 - Related articles - BL Direct - All 5 versions

Disruption of the Transmembrane Dense Core Vesicle Proteins IA-2 and IA-2 {beta} Causes …

- endojournals.org
A Kubosaki, S Nakamura, A Clark, JF Morris, … - Endocrinology, 2006 - Endocrine Soc
Female infertility is a worldwide problem affecting 10–15% of the population.
The cause of the infertility in many cases is not known. In the present report,
we demonstrate that alterations in two transmembrane structural proteins, ...
Cited by 10 - Related articles - BL Direct - All 5 versions

Targeted disruption of the IA-2β gene causes glucose intolerance and impairs insulin …


A Kubosaki, S Gross, J Miura, K Saeki, M Zhu … - Diabetes, 2004 - Am Diabetes Assoc
Insulinoma-associated protein (IA)-2β, also known as phogrin, is an
enzymatically inactive member of the transmembrane protein tyrosine phosphatase
family and is located in dense-core secretory vesicles. In patients with ...
Cited by 26 - Related articles - BL Direct - All 8 versions

The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and …

- nih.gov
S Harashima, A Clark, MR Christie, AL … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences
IA-2 is an enzymatically inactive member of the transmembrane protein tyrosine
phosphate family located in dense core secretory vesicles and a major
autoantigen in type 1 diabetes. Recent studies showed that targeted ...
Cited by 27 - Related articles - All 9 versions

Dense Core Vesicle Proteins IA-2 and IA-2


A Kubosaki, S Nakamura, AL Notkins - 糖尿病学杂志, 2005 - journal.shouxi.net
IA-2 and IA-2 are members of the transmembrane protein tyrosine phosphatase
family located in dense core vesicles of neuroendocrine cells, including the
-cells of pancreatic islets. In the present study, by mating C57BL/6Nci ...
Related articles - Cached

Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins …

- endocrinology-journals.org
JC Henquin, M Nenquin, A Szollosi, A … - Journal of Endocrinology, 2008 - Soc Endocrinology
Islet antigen-2 (IA-2 or ICA 512) and IA-2β (or phogrin) are major autoantigens
in type 1 diabetes. They are located in dense core secretory vesicles including
insulin granules, but their role in β-cell function is unclear. Targeted ...
Cited by 3 - Related articles - BL Direct - All 2 versions

Disturbances in the secretion of neurotransmitters in IA-2/IA-2β null mice: Changes in …


T Nishimura, A Kubosaki, Y Ito, AL Notkins - Neuroscience, 2009 - Elsevier
Islet-associated protein 2 (IA-2) and IA-2β are major autoantigens in type 1
diabetes and transmembrane proteins in dense core secretory vesicles (DCV) of
neuroendocrine cells. The deletion of these genes results in a decrease in ...
Cited by 2 - Related articles

Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in …

- diabetesjournals.org
K Saeki, M Zhu, A Kubosaki, J Xie, MS Lan, … - Diabetes, 2002 - Am Diabetes Assoc
IA-2 is a major autoantigen in type 1 diabetes. Autoantibodies to IA-2 appear
years before the development of clinical disease and are being widely used as
predictive markers to identify individuals at risk for developing type 1 ...
Cited by 61 - Related articles - BL Direct - All 4 versions

The IA-2 interactome

- umich.edu [PDF] 
YF Hu, HL Zhang, T Cai, S Harashima, AL … - Diabetologia, 2005 - Springer
Abstract Aims/hypothesis: Islet antigen-2 (IA-2), a major autoantigen in type 1
diabetes, is an enzymatically inactive member of the transmembrane protein
tyrosine phosphatase (PTP) family. IA-2 is located in dense-core secretory ...
Cited by 4 - Related articles - BL Direct - All 4 versions

Developmental expression and localization of IA-2 mRNA in mouse neuroendocrine tissues


S Shimizu, N Saito, A Kubosaki, S SungWook … - Biochemical and Biophysical Research …, 2001 - Elsevier
Islet antigen (IA)-2 is a novel autoantigen of insulin-dependent diabetes
mellitus (IDDM), and belongs to a new class within the receptor-type protein
tyrosine phosphatase (PTP) family characterized by lack of PTP enzymatic ...
Cited by 4 - Related articles - BL Direct - All 5 versions


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