- ►diabetesjournals.org GS Hotamisligil - Diabetes, 2005 - Am Diabetes Assoc Metabolic and immune systems are the most fundamental requirements for survival,
and many metabolic and immune response pathways or nutrient- and
pathogen-sensing systems have been evolutionarily highly conserved. ... Cited by 104 - Related articles - BL Direct - All 7 versions
医学期刊， 医学会议， 医学教育， 医学书店， … - journal.shouxi.net Over the last decade, an abundance of evidence has emerged demonstrating a close
link between metabolism and immunity. It is now clear that obesity is associated
with a state of chronic low-level inflammation. In this article, we discuss ... Related articles - Cached - All 2 versions
- ►nih.gov KE Wellen, GS Hotamisligil - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Over the last decade, an abundance of evidence has emerged demonstrating a close
link between metabolism and immunity. It is now clear that obesity is associated
with a state of chronic low-level inflammation. In this article, we discuss ... Cited by 774 - Related articles - All 15 versions
- ►pnas.org G Tuncman, J Hirosumi, G Solinas, L Chang, M … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences The c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and
interfere with insulin action in cultured cells and whole animals. Obesity
increases total JNK activity, and JNK1, but not JNK2, deficiency results in ... Cited by 69 - Related articles - BL Direct - All 8 versions
Y Nakatani, H Kaneto, D Kawamori, K … - Journal of Biological Chemistry, 2005 - ASBMB Type 2 diabetes is one of the most prevalent and serious metabolic diseases in
the world, and insulin resistance and pancreatic -cell dysfunction are the
hallmarks of the disease. In this study, we have shown that endoplasmic ... Cited by 144 - Related articles - All 5 versions
LM Miranda-Garduño, A Reza-Albarrán - Gac Méd Méx, 2008 - medigraphic.com *Correspondencia y solicitud de sobretiros: Alfredo A. Reza-Albarrán.
Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias
Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Col. Sección ... Related articles - All 5 versions
J Téllez-Mendoza, J Blangero, AG Comuzzie - Revista de Endocrinología y Nutrición, 2006 - medigraphic.com Raúl A Bastar Raúl A Bastarrachea,* Joanne E Cur rachea,* Joanne E Cur
rachea,* Joanne E Curran,* Victoria Eugenia Bolado,** Jack Kent Jr ictoria
Eugenia Bolado,** Jack Kent Jr ictoria Eugenia Bolado,** Jack Kent Jr,* ... Related articles - All 3 versions
U Ozcan, E Yilmaz, L Ozcan, M Furuhashi, E … - Science, 2006 - sciencemag.org Endoplasmic reticulum (ER) stress is a key link between obesity, insulin
resistance, and type 2 diabetes. Here, we provide evidence that this mechanistic
link can be exploited for therapeutic purposes with orally active chemical ... Cited by 269 - Related articles - BL Direct - All 8 versions
- ►nih.gov G Solinas, W Naugler, F Galimi, MS Lee, M … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences JNKs are attractive targets for treatment of obesity and type-2 diabetes. A
sustained increase in JNK activity was observed in dietary and genetic models of
obesity in mice, whereas JNK deficiency prevented obesity-induced insulin ... Cited by 56 - Related articles - BL Direct - All 14 versions
- ►upenn.edu [PDF] U Ozcan, Q Cao, E Yilmaz, AH Lee, NN … - Science's STKE, 2004 - stke.sciencemag.org Abstract: Obesity contributes to the development of type 2 diabetes, but the
underlying mechanisms are poorly understood. Using cell culture and mouse
models, we show that obesity causes endoplasmic reticulum (ER) stress. This ... Cited by 593 - Related articles - All 17 versions
