- ►diabetesjournals.org FM Matschinsky, MA Magnuson, D Zelent, TL … - Diabetes, 2006 - Am Diabetes Assoc The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and
molecular genetic features that are ideal for its primary role as glucose sensor
in a network of neuro/endocrine sentinel cells that maintain glucose ... Cited by 74 - Related articles - BL Direct - All 10 versions
GL Hypo, H Syndromes, F Outlook - members.medscape.com Glucokinase was discovered ~40 years ago independently in three laboratories,
and tissue surveys at the time indicated that the enzyme was liver specific,
serving a critical role in postprandial glucose clearing from the ... Related articles
GL Hypo, H Syndromes, F Outlook - members.medscape.com The glucokinase glucose sensor paradigm, glucokinase disease, and the potential
of glucokinase activator drugs for diabetes therapy as discussed in this article
can be fully comprehended only if the unique biochemical and structural ... Related articles
GL Hypo, H Syndromes, F Outlook - members.medscape.com The potential of glucokinase as a drug target was recognized early on by the
lead author and researchers at Hoffmann-La Roche, and in the early 1990s the
company embarked on a drug discovery program to explore this opportunity. ... Related articles
GL Hypo, H Syndromes, F Outlook - members.medscape.com The insulin-producing ß-cell functions as a glucostat and is perhaps the most
prominent in a cast of many well-known players participating in maintaining
glucose homeostasis. [47-50] The ß-cell may also be conceptualized as a ... Related articles
GL Hypo - members.medscape.com In view of the preeminent role of glucokinase in the regulatory glucose sensor
system and the hepato-parenchymal high-capacity glucose disposal system, it is
perhaps not surprising that mutations of the glucokinase gene have a ... Related articles
F Outlook - members.medscape.com This brief 2005 perspective about the role of glucokinase in glucose homeostasis
provides also an indication on what can be expected from future research on this
topic. Front and center will be results on clinical trials using GKAs in ... Related articles
GL Hypo, H Syndromes, F Outlook - members.medscape.com There are many known glucokinase-containing cell and tissue types (eg,
hepato-parenchymal and hepato-portal cells, pancreatic α- and ß-cells,
entero-endocrine K- and L-cells, pituitary cells, and neurons of various ... Related articles
FM Matschinsky, MA Magnuson, D Zelent, TL … - DIABETES, 2006 - Am Diabetes Assoc Page 1. Perspectives in Diabetes The Network of Glucokinase-Expressing Cells in
Glucose Homeostasis and the Potential of Glucokinase Activators ... Related articles - All 2 versions
- ►endojournals.org AM Efanov, DG Barrett, MB Brenner, SL Briggs … - Endocrinology, 2005 - Endocrine Soc The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose
metabolism. We report here the effects of a novel glucokinase activator,
LY2121260. The activator enhanced GK activity via binding to the allosteric ... Cited by 55 - Related articles - BL Direct - All 5 versions
