A Brehm, M Krssak, AI Schmid, P Nowotny, W … - Diabetes, 2006 - Am Diabetes Assoc Insulin resistance correlates with intramyocellular lipid content (IMCL) and
plasma free fatty acids (FFAs) and was recently linked to mitochondrial
dysfunction. We examined the underlying relationships by measuring skeletal ... Cited by 56 - Related articles - BL Direct - All 7 versions
J Szendroedi, AI Schmid, M Chmelik, C Toth, … - PLoS Med, 2007 - medicine.plosjournals.org We measured G-6-P, ATP synthetic flux (ie, synthesis) and lipid contents of
skeletal muscle with 31 P/ 1 H magnetic resonance spectroscopy in ten patients
with T2DM and in two control groups: ten sex-, age-, and body mass-matched ... Cited by 40 - Related articles - Cached - All 9 versions
KF Petersen, S Dufour, GI Shulman - PLoS Medicine, 2005 - medicine.plosjournals.org Rates of insulin-stimulated muscle mitochondrial ATP synthase flux and
insulin-stimulated increases in concentrations of intramyocellular inorganic
phosphate (P i ) were assessed by 31 P magnetic resonance spectroscopy ... Cited by 101 - Related articles - Cached - BL Direct - All 12 versions
M Roden - International Journal of Obesity, 2005 - nature.com REL-DM exhibit defects in mitochondrial oxidation and phosphorylation. Increased
FFA availability results in accumulation of intramyocellular fatty acyl-CoA
(FA-CoA) inducing a series of alterations: (i) inhibition of insulin ... Cited by 42 - Related articles - BL Direct - All 5 versions
M Mogensen, K Sahlin, M Fernström, D … - Diabetes, 2007 - Am Diabetes Assoc We tested the hypothesis of a lower respiratory capacity per mitochondrion in
skeletal muscle of type 2 diabetic patients compared with obese subjects. Muscle
biopsies obtained from 10 obese type 2 diabetic and 8 obese nondiabetic ... Cited by 50 - Related articles - BL Direct - All 6 versions
CS Stump, KR Short, ML Bigelow, JM Schimke … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Mitochondria are the primary site of skeletal muscle fuel metabolism and ATP
production. Although insulin is a major regulator of fuel metabolism, its effect
on mitochondrial ATP production is not known. Here we report increases in ... Cited by 132 - Related articles - BL Direct - All 10 versions
- ►pubget.com [PDF] VB Schrauwen-Hinderling, ME Kooi, MKC … - Diabetologia, 2007 - Springer Page 1. ARTICLE Impaired in vivo mitochondrial function but similar
intramyocellular lipid content in patients with type 2 diabetes ... Cited by 41 - Related articles - BL Direct - All 5 versions
DK Richardson, S Kashyap, M Bajaj, K Cusi, … - Journal of Biological Chemistry, 2005 - ASBMB Page 1. Lipid Infusion Decreases the Expression of Nuclear Encoded
Mitochondrial Genes and Increases Expression of Extracellular ... Cited by 80 - Related articles - All 9 versions
- ►diabetesjournals.org M Krssak, A Brehm, E Bernroider, C … - Diabetes, 2004 - Am Diabetes Assoc Decreased skeletal muscle glucose disposal and increased endogenous glucose
production (EGP) contribute to postprandial hyperglycemia in type 2 diabetes,
but the contribution of hepatic glycogen metabolism remains uncertain. ... Cited by 54 - Related articles - BL Direct - All 4 versions
- ►endojournals.org M Krebs, M Krssak, P Nowotny, D Weghuber, S … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc To test Randle's hypothesis we examined whether free fatty acids (FFAs) affect
glucose-stimulated glucose transport/phosphorylation and allosteric mediators of
muscle glucose metabolism under conditions of fasting peripheral ... Cited by 67 - Related articles - BL Direct - All 5 versions
