- ►diabetesjournals.org M Battaglia, A Stabilini, E Draghici, S Gregori, C … - Diabetes, 2006 - Am Diabetes Assoc Islet transplantation is a cure for type 1 diabetes, but its potential is limited by the need for constant
immunosuppression. One solution to this problem is the induction of transplantation tolerance
mediated by T regulatory cells. T regulatory type 1 (Tr1) cells are characterized by their ... Cited by 75 - Related articles - BL Direct - All 6 versions
M Battaglia, A Stabilini, E Draghici, B Migliavacca, S … - Diabetes, 2006 - Am Diabetes Assoc Success in developing novel therapies to recommence self-tolerance in autoimmunity depends
on the induction of T regulatory (Tr) cells. Here, we report that rapamycin combined with interleukin
(IL)-10 efficiently blocks type 1 diabetes development and induces long-term ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►bloodjournal.org M Battaglia, A Stabilini, MG Roncarolo - Blood, 2005 - Am Soc Hematology Rapamycin, a macrolide antibiotic produced by Streptomyces hygroscopicus, is a new effective
drug used to prevent allograft rejection. 1 Similarly to the immunosuppressants FK506 and cyclosporin
A (CsA), rapamycin exerts its effect by binding to the intracellular immunophilin FK506- ... Cited by 252 - Related articles - All 6 versions
- ►jimmunol.org M Battaglia, A Stabilini, B Migliavacca, J … - The Journal of …, 2006 - Am Assoc Immnol CD4 + CD25 + FOXP3 + T regulatory cells (Tregs) are pivotal for the induction and maintenance
of peripheral tolerance in both mice and humans. Rapamycin has been shown to promote tolerance
in experimental models and to favor CD4 + CD25 + Treg-dependent suppression. We ... Cited by 102 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org D Valmori, V Tosello, NE Souleimanian, E … - The Journal of …, 2006 - Am Assoc Immnol Rapamycin is an immunosuppressive drug currently used in different clinical settings. Although
the capacity of rapamycin to inhibit the mammalian target of rapamycin serine/threonine protein
kinase and therefore T cell cycle progression is well known, its effects are complex and ... Cited by 54 - Related articles - BL Direct - All 5 versions
M Battaglia, S Gregori, R Bacchetta, MG Roncarolo - Seminars in Immunology, 2006 - Elsevier Peripheral tolerance is mediated by multiple mechanisms such as anergy and/or active suppression
of effector T cells by T regulatory (Tr) cells. Among the CD4 + Tr cells, T regulatory type 1 cells
(Tr1) have been shown to down-modulate immune responses through production of the ... Cited by 84 - Related articles - All 2 versions
MG Roncarolo, M Battaglia - 2005 - freepatentsonline.com 1. The use of a combined pharmaceutical preparation containing IL-10 and rapamycin as the
sole active ingredients for the manufacture of a medicament for inducing antigen-specific immune
tolerance in a subject affected by an autoimmune disease. ... 2. The use according to ... Related articles - All 2 versions
MG Roncarolo, M Battaglia - US Patent App. 11/839,676, 2007 - Google Patents Patent Application Publication Mar. 20, 2008 Sheet 3 of 12 US 2008/0069797 Al FIGURE 3
!L-10 Edmonton control protocol protocol untranspianted ... Patent Application Publication
Mar. 20, 2008 Sheet 5 of 12 US 2008/0069797 Al FIGURE 5 CD4 20 IL-10 Edmonton ... Related articles - All 8 versions
- ►jimmunol.org L Strauss, TL Whiteside, A Knights, C … - The Journal of …, 2007 - Am Assoc Immnol Naturally occurring CD4 + CD25 + regulatory T (nTreg) cells are essential for maintaining T cell
tolerance to self Ags. We show that discrimination of human Treg from effector CD4 + CD25 +
non-nTreg cells and their selective survival and proliferation can now be achieved using ... Cited by 98 - Related articles - BL Direct - All 5 versions
- ►rupress.org S Gregori, P Mangia, R Bacchetta, E Tresoldi, … - Journal of Experimental …, 2005 - jem.rupress.org The effects of a chimeric monoclonal antibody (chA6 mAb) that recognizes both the RO and RB
isoforms of the transmembrane protein tyrosine phosphatase CD45 on human T cells were
investigated. Chimeric A6 (chA6) mAb potently inhibited antigen-specific and polyclonal T ... Cited by 32 - Related articles - All 8 versions
