- ►diabetesjournals.org J Endl, S Rosinger, B Schwarz, SO Friedrich, G Rothe, … - Diabetes, 2006 - Am Diabetes Assoc T-cell–mediated loss of pancreatic ß-cells is the crucial event in the development of type 1
diabetes. The phenotypic characteristics of disease-associated T-cells in type 1 diabetes have
not yet been defined. The negative results from two intervention trials (the Diabetes ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►alaskaclinicaltrials.org [PDF] V Öling, J Marttila, J Ilonen, WW Kwok, G Nepom, M … - Journal of Autoimmunity, 2005 - Elsevier In type 1 diabetes the major loss of insulin producing beta-cells is caused by autoreactive T-cells
specific for antigens expressed by the pancreatic islets. In this study we have analyzed the prevalence
of glutamate decarboxylase 65 (GAD65)- and proinsulin-specific CD4 + T-cells in type 1 ... Cited by 23 - Related articles - All 8 versions
PR Streeter, X Zhang, TV Tittle, CN Schön, AD … - Biology of Blood and …, 2004 - Elsevier CD134 (OX40) is expressed on activated CD4 + donor T cells in allogeneic stem cell transplant
recipients with acute graft-versus-host disease. The data presented here reveal that differential
expression of CD25 by CD4 + CD134 + T cells allows separation of these activated cells ... Cited by 10 - Related articles - BL Direct - All 6 versions
CML Munier, JJ Zaunders, S Ip, DA Cooper, AD … - Journal of Immunological …, 2009 - Elsevier Ex-vivo T-cell responses to vaccines and some viral antigens are not always detectable by conventional
functional T-cell assays such as lympho-proliferation assays, IFN-γ ELIspot and intracellular
cytokine staining (ICC). In this study we describe the development, optimisation and ... Cited by 2 - Related articles - All 2 versions
- ►jbc.org AY Savinov, DV Rozanov, AY Strongin - Journal of Biological Chemistry, 2007 - ASBMB Human diabetes mellitus (IDDM; type I diabetes) is a T cell-mediated disease that is closely modeled
in non-obese diabetic (NOD) mice. The pathogenesis of IDDM involves the transmigration of
autoimmune T cells into the pancreatic islets and the subsequent destruction of insulin- ... Cited by 3 - Related articles - All 4 versions
R De Rose, RD Mason, L Loh, V Peut, … - Journal of Medical …, 2008 - microbiol.unimelb.edu.au Immune control of HIV in humans and SIV in maca- ques can occur naturally but is rare. Substantial
evi- dence links T cell immune responses with control of viremia [16, 17], but inducing more effective
T cell immunity with practical immunotherapy techniques has been difficult. Several ... Cited by 2 - Related articles - View as HTML - All 4 versions
EM Zeinstra, N Wilczak, JC Wilschut, L Glazenburg, … - Journal of …, 2006 - Elsevier A failure of tight control of MHC class II expression on astrocytes may play a role in the development
of autoimmune responses in multiple sclerosis. The 5-HT 4 serotonin receptor agonists cisapride
and prucalopride, at concentrations between 10 − 10 M and 10 − 8 M, reduced ... Cited by 4 - Related articles - All 10 versions
H Tsui, Y Chan, L Tang, S Winer, RK Cheung, G … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— pSC cultures did not express major histocompatibility complex (MHC) class II and
were lysed by ex vivo CTLs from diabetic NOD mice. In vivo, restoration of MHC class I in
GFAP-β2m transgenics significantly accelerated adoptively transferred diabetes. Target ... Cited by 4 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org P Monti, M Scirpoli, A Rigamonti, A Mayr, A … - The Journal of …, 2007 - Am Assoc Immnol Identifying cell autoantigen-reactive T cells that are involved in the pathogenesis of type 1 diabetes
has been troublesome for many laboratories. Disease-relevant autoreactive T cells should be
in vivo Ag experienced. The aim of this study was to test this hypothesis and then use this ... Cited by 17 - Related articles - All 4 versions
CD Sharp, M Huang, J Glawe, DR Patrick, S Pardue, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—TNF- significantly increased NOD/LtJ T-cell adhesion, which was completely blocked
by SDF-1 in a dose-dependent manner, revealing a novel chemorepulsive effect.
Conversely, SDF-1 enhanced C57BL/6J T-cell adhesion to TNF- –activated islet ... Cited by 4 - Related articles - BL Direct - All 4 versions
