- ►diabetesjournals.org AV Poll, CE Pierreux, L Lokmane, C Haumaitre, Y … - Diabetes, 2006 - Am Diabetes Assoc Generation of pancreatic precursor cells in the endoderm is controlled by a network of transcription
factors. Hepatocyte nuclear factor-6 (HNF6) is a key player in this network, because it controls
the initiation of the expression of pancreatic and duodenal homeobox 1 (Pdx1), the ... Cited by 28 - Related articles - BL Direct - All 6 versions
EL Edghill, C Bingham, AS Slingerland, JA … - Diabetic …, 2006 - interscience.wiley.com Aim The transcription factor hepatocyte nuclear factor-1beta (HNF-1β) is expressed in rodent
pancreatic progenitor cells, where it is an important member of the genetic hierarchy that regulates
the generation of pancreatic endocrine and exocrine cells. The recent description of an ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►pnas.org C Haumaitre, E Barbacci, M Jenny, MO … - Proceedings of the …, 2005 - National Acad Sciences Heterozygous mutations in the human POU-homeobox TCF2 (vHNF1, HNF1β) gene are associated
with maturity-onset diabetes of the young, type 5, and abnormal urogenital tract
development. Recently, pancreas atrophies have been reported in several maturity-onset ... Cited by 58 - Related articles - All 9 versions
- ►endojournals.org T Yorifuji, K Kurokawa, M Mamada, T Imai, M … - Journal of Clinical …, 2004 - Endocrine Soc Mutations in the gene coding for hepatocyte nuclear factor-1ß (HNF-1ß) have been known to
cause a form of maturity-onset diabetes of the young (MODY5), which is usually characterized
by dominantly inherited adolescence-onset diabetes mellitus associated with renal cysts. ... Cited by 30 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org LW Harries, S Ellard, A Stride… - Human Molecular Genetics, 2006 - Oxford Univ Press The generation of multiple transcripts by mRNA processing has the potential to moderate differences
in gene expression both between tissues and at different stages of development. Where gene
function is compromised by mutation, the presence of multiple isoforms may influence the ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►endojournals.org VM Schwitzgebel, A Mamin, T Brun, B Ritz- … - Journal of Clinical …, 2003 - Endocrine Soc Neonatal diabetes mellitus can be transient or permanent. The severe form of permanent neonatal
diabetes mellitus can be associated with pancreas agenesis. Normal pancreas development
is controlled by a cascade of transcription factors, where insulin promoter factor 1 (IPF1) ... Cited by 48 - Related articles - BL Direct - All 6 versions
T Nammo, K Yamagata, T Tanaka, T Kodama, FM … - Gene Expression …, 2007 - Elsevier The type 1, 3, and 5 forms of maturity-onset diabetes of the young (MODY) are caused by mutations
of the genes encoding hepatocyte nuclear factor (HNF)-4α, HNF-1α, and HNF-1β, respectively
[Yamagata, K., Oda, N., Kaisaki, PJ, Menzel, S., Furuta, H., Vaxillaire, M., et al., 1996a. ... Cited by 5 - Related articles - All 2 versions
T Nammo, K Yamagata, R Hamaoka, Q Zhu, T Akiyama … - Diabetologia, 2002 - Springer Aims/hypothesis. One subtype of MODY (MODY3) re- sults from the heterozygous mutation of
a hepatocyte nu- clear factor (HNF)-1α. The pattern of HNF-1α expres- sion in the normal pancreas
has not been determined. This study aimed to clarify the profile of HNF-1α pro- tein ... Cited by 17 - Related articles - BL Direct - All 3 versions
- ►nih.gov PO Wiebe, JD Kormish, VT Roper, Y Fujitani, … - Molecular and cellular …, 2007 - Am Soc Microbiol The critical pancreatic transcription factor Pdx1 is expressed throughout the pancreas early but
enriched in insulin-producing ß cells postnatally. Previous studies showed that the 5' conserved
promoter regions areas I and II (Pdx1 PB ) direct endocrine cell expression, while an ... Cited by 18 - Related articles - BL Direct - All 8 versions
- ►endojournals.org S Kitanaka, Y Miki, Y Hayashi, T Igarashi - Journal of Clinical …, 2004 - Endocrine Soc Mutations in the hepatocyte nuclear factor (HNF)-1ß lead to type 5 maturity-onset diabetes of
the young (MODY5). HNF-1ß forms a homodimer or a heterodimer with HNF-1 and regulates
various target genes. HNF-1ß mutations are rare, and no functional analysis has been ... Cited by 17 - Related articles - BL Direct - All 5 versions
