AL Carey, GR Steinberg, SL Macaulay, WG Thomas, … - Diabetes, 2006 - Am Diabetes Assoc Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding
the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusion increases
glucose disposal without affecting the complete suppression of endogenous glucose ... Cited by 99 - Related articles - BL Direct - All 6 versions
- ►endojournals.org L Al-Khalili, K Bouzakri, S Glund, F Lonnqvist, … - Molecular …, 2006 - Endocrine Soc We identified signaling pathways by which IL-6 regulates skeletal muscle differentiation and
metabolism. Primary human skeletal muscle cells were exposed to IL-6 (25 ng/ml either acutely
or for several days), and small interfering RNA gene silencing was applied to measure ... Cited by 49 - Related articles - BL Direct - All 6 versions
- ►physiology.org EW Petersen, AL Carey, M Sacchetti, GR … - American Journal of …, 2005 - Am Physiological Soc To determine whether IL-6 increases lipolysis and fat oxidation in patients with type 2 diabetes
and/or whether it exerts this effect independently of changes to the hormonal milieu, patients
with type 2 diabetes (D) and healthy control subjects (CON) underwent recombinant ... Cited by 64 - Related articles - All 6 versions
- ►jbc.org C Weigert, AM Hennige, R Lehmann, K Brodbeck, F … - Journal of Biological …, 2006 - ASBMB The exercise-induced interleukin (IL)-6 production and secretion within skeletal muscle fibers
has raised the question of a putative tissue-specific function of IL-6 in the energy metabolism
of the muscle during and after the exercise. In the present study, we followed the ... Cited by 37 - Related articles - BL Direct - All 6 versions
- ►bkpgroup.dk [PDF] M Kelly, C Keller, PR Avilucea, P Keller, Z Luo, X … - … and Biophysical Research …, 2004 - Elsevier Following exercise, AMP-activated protein kinase (AMPK) activity is increased several fold in
rat liver and adipose tissue as well as muscle; however, the mechanism by which this occurs
is not known. Interleukin-6 (IL-6) is released from muscle in large amounts during and ... Cited by 98 - Related articles - All 6 versions
- ►diabetesjournals.org MA Febbraio, N Hiscock, M Sacchetti, CP Fischer, BK … - Diabetes, 2004 - Am Diabetes Assoc The mechanisms that mediate the tightly controlled production and clearance of glucose during
muscular work are unclear, and it has been suggested that an unidentified “work factor” exists
that influences the contraction-induced increase in endogenous glucose production ... Cited by 84 - Related articles - BL Direct - All 5 versions
A Steensberg, CP Fischer, M Sacchetti, C … - The Journal of …, 2003 - Physiological Soc The cytokine interleukin (IL)-6 has recently been linked with type 2 diabetes mellitus and has
been suggested to affect glucose metabolism. To determine whether acute IL-6 administration
affects whole-body glucose kinetics or muscle glucose uptake, 18 healthy young men ... Cited by 86 - Related articles - BL Direct - All 9 versions
- ►endojournals.org G van Hall, A Steensberg, M Sacchetti, C … - Journal of Clinical …, 2003 - Endocrine Soc Although IL-6 is a key modulator of immune function, it also plays a role in regulating substrate
metabolism. To determine whether IL-6 affects lipid metabolism, 18 healthy men were infused
for 3 h with saline (Con; n = 6) or a high dose (High-rhIL6; n = 6) or a low dose ... Cited by 179 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org HJ Kim, T Higashimori, SY Park, H Choi, J Dong, YJ … - Diabetes, 2004 - Am Diabetes Assoc The circulating level of the inflammatory cytokine interleukin (IL)-6 is elevated in various
insulin-resistant states including type 2 diabetes, obesity, cancer, and HIV-associated
lipodystrophy. To determine the role of IL-6 in the development of insulin resistance, we ... Cited by 166 - Related articles - BL Direct - All 4 versions
