- ►diabetesjournals.org K Maedler, DM Schumann, N Sauter, H … - Diabetes, 2006 - Am Diabetes Assoc High glucose concentrations have a dual effect on β-cell turnover, inducing
proliferation in the short-term and apoptosis in the long-term. Hyperglycemia
leads to β-cell production of interleuking (IL)-1β in human pancreatic ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►pnas.org DM Schumann, K Maedler, I Franklin, D Konrad … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Pancreatic β cell mass and function increase in conditions of enhanced insulin
demand such as obesity. Failure to adapt leads to diabetes. The molecular
mechanisms controlling this adaptive process are unclear. Fas is a death ... Cited by 21 - Related articles - BL Direct - All 11 versions
K Maedler, DM Schumann, N Sauter, H … - Diabetes, 2006 - Am Diabetes Assoc T he capacity of the pancreatic -cell to adaptively increase insulin secretion
in response to long- term insulin resistance (for example in obesity) is
fundamental to the maintenance of normogly- cemia. Failure of such a ... Cited by 9 - Related articles - All 3 versions
K Maedler, DM Schumann, N Sauter, H … - 糖尿病学杂志, 2006 - journal.shouxi.net High glucose concentrations have a dual effect on -cell turnover, inducing
proliferation in the short-term and apoptosis in the long-term. Hyperglycemia
leads to -cell production of interleuking (IL)-1 in human pancreatic ... Related articles - Cached
- ►endojournals.org NS Sauter, FT Schulthess, R Galasso, LW … - Endocrinology, 2008 - Endocrine Soc Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes.
Elevated cytokines impair β-cell function and survival. A recent clinical trial
shows that blocking IL-1β signaling by IL-1 receptor antagonist (IL-1Ra) ... Cited by 19 - Related articles - BL Direct - All 4 versions
[CITATION] Gene expression profile in the pancreatic islets of Goto-Kakizaki (GK) rats with repeated …
- ►diabetesjournals.org K Maedler, DM Schumann, F Schulthess, J … - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by a deficit in β-cell mass, and its incidence
increases with age. Here, we analyzed β-cell turnover in islets from 2- to 3-
compared with 7- to 8-month-old rats and in human islets from 53 organ ... Cited by 29 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org N Welsh, M Cnop, I Kharroubi, M Bugliani, R … - Diabetes, 2005 - Am Diabetes Assoc Different degrees of β-cell failure and apoptosis are present in type 1 and
type 2 diabetes. It has been recently suggested that high glucose–induced
β-cell apoptosis in type 2 diabetes shares a final common pathway with ... Cited by 40 - Related articles - BL Direct - All 6 versions
K Maedler, P Sergeev, JA Ehses, Z Mathe, D … - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences High concentrations of glucose induce β cell production of IL-1β, leading to
impaired β cell function and apoptosis in human pancreatic islets. IL-1
receptor antagonist (IL-1Ra) is a naturally occurring antagonist of IL-1β ... Cited by 82 - Related articles - BL Direct - All 13 versions
R Marculescu, G Endler, M Schillinger, N … - Diabetes, 2002 - Am Diabetes Assoc Recently, inflammation has received considerable attention in the pathogenesis
of both type 2 diabetes and atherosclerosis. The interleukin-1 receptor
antagonist (IL-1ra) is a major modulator of the interleukin-1 ... Cited by 34 - Related articles - BL Direct - All 5 versions
