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Scholar Results 1 - 10 of about 101 related to Johnson: Suppressed insulin signaling and increased apoptosis in CD38-null islets. (0.10 sec) 

Suppressed insulin signaling and increased apoptosis in CD38-null islets

- diabetesjournals.org
JD Johnson, EL Ford, E Bernal-Mizrachi, KL … - Diabetes, 2006 - Am Diabetes Assoc
CD38 is a multifunctional enzyme capable of generating metabolites that release
Ca 2+ from intracellular stores, including nicotinic acid adenine dinucleotide
phosphate (NAADP). A number of studies have led to the controversial ...
Cited by 8 - Related articles - BL Direct - All 5 versions

Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a …

- jbc.org
Q Liu, IA Kriksunov, C Moreau, R Graeff, BVL … - Journal of Biological Chemistry, 2007 - ASBMB
Cyclic ADP-ribose (cADPR) is a calcium mobilization messenger important for
mediating a wide range of physiological functions. The endogenous levels of
cADPR in mammalian tissues are primarily controlled by CD38, a ...
Cited by 1 - Related articles - All 6 versions

Acute effects of insulin on beta-cells from transplantable human islets


DS Luciani, JD Johnson - Molecular and cellular endocrinology, 2005 - Elsevier
The functional role of autocrine insulin signaling remains unclear despite
considerable investigation. In the present study, we tested the effects of high
and low doses of exogenous insulin on Ca 2+ signaling, insulin synthesis ...
Cited by 9 - Related articles - All 3 versions

Regulation of SIRT 1 mediated NAD dependent deacetylation: A novel role for the …


P Aksoy, C Escande, TA White, M Thompson, … - Biochemical and Biophysical Research …, 2006 - Elsevier
The SIRT 1 enzyme is a NAD dependent deacetylase implicated in ageing, cell
protection, and energy metabolism in mammalian cells. How the endogenous
activity of SIRT 1 is modulated is not known. The enzyme CD38 is a ...
Cited by 9 - Related articles - All 5 versions

Anti-CD 38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus


C Pupilli, A Antonelli, L Iughetti, G D' … - Journal of pediatric endocrinology & metabolism, 2005 - cat.inist.fr
Aims: To test for anti-CD 38 autoimmunity in children with newly-diagnosed type
1 diabetes mellitus(DM 1). Methods: Serum anti-CD 38 autoantibodies were
detected by Western blot in 270 children(130 girls, 140 boys, mean age 8 ...
Cited by 4 - Related articles - BL Direct - All 2 versions

The enzyme CD38 (a NAD glycohydrolase, EC 3.2. 2.5) is necessary for the development of …

- fasebj.org
MTP Barbosa, SM Soares, CM Novak, D … - The FASEB Journal, 2007 - FASEB
Obesity is one of the major health problems of our times. Elucidating the
signaling mechanisms by which high-fat caloric diet induces obesity is critical
for the understanding of this condition and for the development of ...
Cited by 11 - Related articles - BL Direct - All 4 versions

Prolonged in vitro exposure to autoantibodies against CD38 impairs the function and …

- diabetesjournals.org
P Marchetti, A Antonelli, R Lupi, L Marselli, P … - Diabetes, 2002 - Am Diabetes Assoc
Autoantibodies against CD38 (adenosine-5′-diphosphate[ADP]-ribosyl
cyclase/cyclic ADP-ribose hydrolase) have been described in 10–12% of patients
with type 2 diabetes. In human islets, anti-CD38 autoantibodies (CD38Abs) ...
Cited by 6 - Related articles - BL Direct - All 3 versions

Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by gender


J Takahashi, Y Kagaya, I Kato, J Ohta, S … - Biochemical and biophysical research communications, 2003 - Elsevier
To elucidate whether myocardial CD38/cyclic ADP-ribose (cADPR) signaling plays a
physiological role, we investigated the heart of CD38 knockout mice (CD38KO). In
CD38KO, the myocardial cADPR content was reduced by 85% compared with ...
Cited by 14 - Related articles - All 5 versions

Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing …

- jimmunol.org
J Chen, YG Chen, PC Reifsnyder, WH Schott, … - The Journal of Immunology, 2006 - Am Assoc Immnol
Ubiquitously expressed CD38 and T cell-expressed ADP-ribosyltransferase 2 (ART2)
are ectoenzymes competing for NAD substrate. CD38 exerts pleiotropic actions in
hemopoietic and nonhemopoietic compartments via effects on calcium ...
Cited by 9 - Related articles - All 4 versions

Retrospective Analysis of CD38 Expression in 102 Patients with B-CLL with a Maximum …


A Jakob, J Doll, J Schulte-Mönting, FW Hirsch - Onkologie, 2006 - content.karger.com
Dr. med. Andreas Jakob Klinikum Offenburg, Medizinische Klinik II Ebertplatz 12,
77654 Offenburg, Germany Tel. +49 781 472-2503, Fax -2402 E-mail
dr.jakob@gmx.net ... © 2006 S. Karger GmbH, Freiburg Accessible online ...
Cited by 1 - Related articles - BL Direct - All 5 versions


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