- ►shouxi.net A Yao-Borengasser, N Rasouli, V Varma, LM … - Diabetes, 2006 - Am Diabetes Assoc Lipin-α and -β are the alternatively spliced gene products of the Lpin1 gene,
whose product lipin is required for adipocyte differentiation. Lipin deficiency
causes lipodystrophy, fatty liver, and insulin resistance in mice, whereas ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►cell.com J Phan, K Reue - Cell Metabolism, 2005 - Elsevier Lipodystrophy and obesity represent extreme and opposite ends of the adiposity
spectrum and have typically been attributed to alterations in the expression or
function of distinct sets of genes. We previously demonstrated that lipin ... Cited by 77 - Related articles - BL Direct - All 15 versions
- ►angrylapdog.com TE Harris, TA Huffman, A Chi, J Shabanowitz … - Journal of Biological Chemistry, 2007 - jbc.org.p.angrylapdog.com Brain, liver, kidney, heart, and skeletal muscle from fatty liver dystrophy
(fld/fld) mice, which do not express lipin 1 (lipin), contained much less Mg 2+
-dependent phosphatidic acid phosphatase (PAP) activity than tissues from ... Cited by 34 - Related articles - All 8 versions
- ►jlr.org V van Harmelen, M Ryden, E Sjolin, J … - The Journal of Lipid Research, 2007 - ASBMB The mouse lipin gene, Lpin1, is important for adipose tissue development and is
a candidate gene for insulin resistance. Here, we investigate the adipose tissue
expression levels of the human LPIN1 gene in relation to various clinical ... Cited by 26 - Related articles - All 4 versions
- ►jbc.org J Donkor, M Sariahmetoglu, J Dewald, DN … - Journal of Biological Chemistry, 2007 - ASBMB We previously identified mutations in the Lpin1 gene, encoding lipin-1, as the
underlying cause of lipodystrophy in the fatty liver dystrophy (fld) mutant
mouse. Lipin-1 is normally expressed at high levels in adipose tissue and ... Cited by 62 - Related articles - All 6 versions
BN Finck, MC Gropler, Z Chen, TC Leone, MA … - Cell metabolism, 2006 - Elsevier Perturbations in hepatic lipid homeostasis are linked to the development of
obesity-related steatohepatitis. Mutations in the gene encoding lipin 1 cause
hepatic steatosis in fld mice, a genetic model of lipodystrophy. However, ... Cited by 72 - Related articles - All 7 versions
- ►oxfordjournals.org E Suviolahti, K Reue, RM Cantor, J Phan, M … - Human Molecular Genetics, 2006 - Oxford Univ Press Recent studies in the mouse have demonstrated that variations in lipin
expression levels in adipose tissue have marked effects on adipose tissue mass
and insulin sensitivity. In the mouse, lipin deficiency prevents normal ... Cited by 43 - Related articles - BL Direct - All 9 versions
- ►angrylapdog.com MA Croce, JC Eagon, LL LaRiviere, KM … - Diabetes, 2007 - diabetes.diabetesjournals.org.p.angrylapdog.com RESULTS— The expression of lipin 1β in liver and adipose tissue was inversely
related to BMI, fasting plasma insulin concentration, and the homeostasis model
assessment of insulin resistance but was significantly increased by marked ... Cited by 12 - Related articles - BL Direct - All 5 versions
B Lindegaard, LF Larsen, ABE Hansen, J … - International Journal of Obesity, 2006 - nature.com Lipodystrophy is the major complication of antiretroviral therapy in
HIV-infected patients. Its pathophysiology is not well understood, but has been
linked to antiadipogenic effects of antiretroviral drugs. Lipin represents ... Cited by 16 - Related articles - BL Direct - All 4 versions
- ►angrylapdog.com M Peterfy, J Phan, K Reue - Journal of Biological Chemistry, 2005 - ASBMB We recently identified mutations in the Lpin1 (lipin) gene to be responsible for
lipodystrophy in the fatty liver dystrophy (fld) mouse strain. Previous studies
revealed that lipin plays a critical role in adipogenesis, explaining the ... Cited by 62 - Related articles - BL Direct - All 6 versions
