D Muller, GC Huang, S Amiel, PM Jones, SJ Persaud - Diabetes, 2006 - Am Diabetes Assoc Although many studies using rodent islets and insulinoma cell lines have been performed to
determine the role of insulin in the regulation of islet function, the autocrine effect of insulin on
insulin gene expression is still controversial, and no consensus has yet been achieved. ... Cited by 25 - Related articles - BL Direct - All 4 versions
D Muller, GC Huang, S Amiel, PM Jones, SJ Persaud - 糖尿病学杂志, 2006 - journal.shouxi.net Although many studies using rodent islets and insulinoma cell lines have been performed to
determine the role of insulin in the regulation of islet function, the autocrine effect of insulin on
insulin gene expression is still controversial, and no consensus has yet been achieved. ... Related articles - Cached
D Muller, GC Huang, S Amiel, PM Jones, SJ Persaud - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Insulin secretion is a highly regulated mechanism involving a complex
insulin-dependent network of communication between alpha, beta and delta cells. However,
whereas the role of insulin in beta cells has been well documented, very little is known ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►endojournals.org P Ribaux, JA Ehses, N Lin-Marq, F Carrozzino, M Boni- … - Endocrinology, 2007 - Endocrine Soc As we showed previously, the extracellular matrix (ECM) derived from rat bladder carcinoma
cells (804G-ECM) has positive effects on rat primary β-cell function and survival in vitro. The
aim of this study was to define β-cell genes induced by this ECM with a specific focus on ... Cited by 13 - Related articles - BL Direct - All 4 versions
J Cantley, AI Choudhury, H Asare-Anane, C Selman, S … - Diabetologia, 2007 - Springer Page 1. ARTICLE Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha
cell mass and impairs glucose homeostasis in mice J. Cantley & AI Choudhury & H. Asare-Anane
& C. Selman & S. Lingard & H. Heffron & P. Herrera & SJ Persaud & DJ Withers ... Cited by 14 - Related articles - BL Direct - All 4 versions
MK Lingohr, I Briaud, LM Dickson, JF McCuaig, C … - Journal of Biological …, 2006 - ASBMB Insulin receptor substrate 2 (IRS-2) plays a critical role in pancreatic β-cells. Increased IRS-2
expression promotes β-cell growth and survival, whereas decreased IRS-2 levels lead to
apoptosis. It was found that IRS-2 turnover in rat islet β-cells was rapid, with mRNA and ... Cited by 23 - Related articles - BL Direct - All 5 versions
K Bouzakri, P Ribaux, A Tomas, G Parnaud, K … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Protein kinase B/Akt plays a central role in β-cells, but little is known regarding
downstream Akt substrates in these cells. Recently, Rab GTPase-activating protein AS160, a
substrate of Akt, was shown to be involved in insulin modulation of GLUT4 trafficking in ... Cited by 5 - Related articles - BL Direct - All 4 versions
B Yermen, A Tomas, PA Halban - Diabetes, 2007 - Am Diabetes Assoc We have previously shown that the Ca 2+ -dependent actin-severing protein gelsolin plays an
important role in regulated insulin secretion. The aim of this study was to determine the role of
gelsolin in β-cell survival as it has been shown to play a dual role in apoptosis in other ... Cited by 7 - Related articles - BL Direct - All 6 versions
M Ohsugi, C Cras-Meneur, Y Zhou, E Bernal- … - Journal of Biological …, 2005 - ASBMB Running Title: Multiple roles of insulin signaling in islet cells ... Reduced Expression of the Insulin
Receptor in Mouse Insulinoma (MIN6) Cells Reveals Multiple Roles of Insulin Signaling in Gene
Expression, Proliferation, Insulin Content and Secretion. ... Mitsuru Ohsugi, Corentin ... Cited by 39 - Related articles - All 5 versions
M Lawrence, C Shao, L Duan, K McGlynn, MH … - Acta …, 2008 - interscience.wiley.com Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) activities are modulated in a
manner that reflects the secretory demand on β cells to integrate long- and short-term nutrient
sensing information. Our studies have focused on the mechanisms of ERK1/2 activation ... Cited by 11 - Related articles - BL Direct - All 3 versions
