H Sørensen, CL Brand, S Neschen, JJ Holst, … - Diabetes, 2006 - Am Diabetes Assoc In type 2 diabetes, glucagon levels are elevated in relation to the prevailing
insulin and glucose levels. The relative hyperglucagonemia is linked to
increased hepatic glucose output (HGO) and hyperglycemia. Antagonizing the ... Cited by 14 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org SA Qureshi, R Candelore… - Diabetes, 2004 - Am Diabetes Assoc Glucagon maintains glucose homeostasis during the fasting state by promoting
hepatic gluconeogenesis and glycogenolysis. Hyperglucagonemia and/or an elevated
glucagon-to-insulin ratio have been reported in diabetic patients and ... Cited by 18 - Related articles - BL Direct - All 5 versions
- ►nih.gov KW Sloop, JXC Cao, AM Siesky, HY Zhang, DM … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Uncontrolled hepatic glucose production contributes significantly to
hyperglycemia in patients with type 2 diabetes. Hyperglucagonemia is implicated
in the etiology of this condition; however, effective therapies to block ... Cited by 47 - Related articles - BL Direct - All 6 versions
- ►physiology.org Y Anini, A Izzo, GY Oudit, PH Backx, PL … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc Glucagon-like peptide-2 (GLP-2) enhances intestinal growth and function through
a cAMP-linked G protein-coupled receptor (GPCR) expressed in the mucosal layer
and enteric nervous system. Because the type 1B -isoform of ... Cited by 4 - Related articles - BL Direct - All 5 versions
GC Weir, RF Atkins, DB Martin - Metabolism: clinical and experimental, 1976 - ncbi.nlm.nih.gov 1: Metabolism. 1976 Nov;25(11 Suppl 1):1519-21. Glucagon secretion from the perfused
rat pancreas following acute and chronic streptozotocin. ... Cited by 6 - Related articles
Y Liang, MC Osborne, BP Monia, S Bhanot, … - Diabetes, 2004 - Am Diabetes Assoc Excess glucagon levels contribute to the hyperglycemia associated with type 2
diabetes. Reducing glucagon receptor expression may thus ameliorate the
consequences of hyperglucagonemia and improve blood glucose control in ... Cited by 47 - Related articles - BL Direct - All 5 versions
KF Petersen, JT Sullivan - Diabetologia, 2001 - Springer Fasting hyperglycaemia in patients with poorly con- trolled Type II
(non-insulin-dependent) diabetes mellitus is closely associated with increased
rates of glucose production which in turn can be ascribed to increased ... Cited by 62 - Related articles - BL Direct - All 3 versions
Q Dallas-Yang, X Shen, M Strowski, E Brady, … - European journal of pharmacology, 2004 - Elsevier Glucagon receptor antagonists have been actively pursued as potential
therapeutics for the treatment of type 2 diabetes. Peptidyl and non-peptidyl
glucagon receptor antagonists have been shown to block glucagon-induced ... Cited by 8 - Related articles - All 3 versions
- ►endojournals.org BE Dunning, JE Gerich - Endocrine reviews, 2007 - Endocrine Soc The hyperglycemic activity of pancreatic extracts was encountered some 80 yr ago
during efforts to optimize methods for the purification of insulin. The
hyperglycemic substance was named "glucagon," and it was subsequently ... Cited by 32 - Related articles - BL Direct - All 5 versions
GC Webb, MS Akbar, C Zhao, HH Swift, DF … - Diabetes, 2002 - Am Diabetes Assoc Prohormone convertase 2 (PC2) plays an essential role in the processing of
proglucagon to mature active glucagon in pancreatic α-cells (J Biol Chem
276:27197–27202, 2001). Mice lacking PC2 demonstrate multiple defects, ... Cited by 34 - Related articles - BL Direct - All 5 versions
