- ►diabetesjournals.org SC Elbein, X Wang, MA Karim, BI Freedman, … - Diabetes, 2006 - Am Diabetes Assoc African Americans have twice the prevalence of type 2 diabetes as Caucasians and
much greater genetic diversity. We identified an inframe insertion of a proline
in the insulin promoter factor 1 (IPF1) gene (InsCCG243), which was ... Cited by 2 - Related articles - BL Direct - All 5 versions
- ►umaryland.edu [PDF] W Guan, A Pluzhnikov, NJ Cox, M Boehnke - Hum Hered, 2008 - content.karger.com Background: The International Type 2 Diabetes Linkage Analysis Consortium was
formed to localize type 2 diabetes predisposing variants based on 23 autosomal
linkage scans. Methods: We carried out meta-analysis using the genome scan ... Cited by 3 - Related articles - BL Direct - All 10 versions
X Zhu, RS Cooper - PLoS ONE, 2007 - pubmedcentral.nih.gov Migration patterns in modern societies have created the opportunity to use
population admixture as a strategy to identify susceptibility genes. To
implement this strategy, we genotyped a highly informative ancestry marker ... Cited by 3 - Related articles - All 8 versions
SC Elbein, X Wang, MA Karim, WS Chu, KD … - BMC Medical Genetics, 2006 - biomedcentral.com Betacellulin is a member of the epidermal growth factor family, expressed at the
highest levels predominantly in the pancreas and thought to be involved in islet
neogenesis and regeneration. Nonsynonymous coding variants were reported to ... Cited by 4 - Related articles - Cached - All 9 versions
SJ Hasstedt, WS Chu, SK Das, H Wang, SC … - Annals of Human Genetics, 2008 - interscience.wiley.com Type 2 diabetes (T2D) has been linked to chromosome 1q21–24 in multiple
samples, including a Utah family sample. Variants in 13 of the numerous
candidate genes in the 1q region were tested for association with T2D in a ... Cited by 4 - Related articles - BL Direct - All 3 versions
MA Karim, X Wang, TC Hale, SC Elbein - BMC Medical Genetics, 2005 - biomedcentral.com We identified 8 variants in the two populations, including a 3 bp insertion in
exon 2 (InsCCG243) in African Americans that resulted in an in-frame proline
insertion in the transactivation domain. No variant was associated with ... Cited by 12 - Related articles - Cached - All 8 versions
KR Owen, JC Evans, MI McCarthy, M Walker, … - Diabetologia, 2004 - Springer To the Editor: Insulin promoter factor-1 (IPF-1, PDX-1) is a transcription
factor and homeodomain protein required for de- velopment of the pancreas and
initiation and maintenance of the insulin-secreting phenotype of the beta ... Cited by 5 - Related articles - BL Direct - All 4 versions
SC Elbein - Current Opinion in Clinical Nutrition & Metabolic Care, 2007 - journals.lww.com Purpose of review Populations of direct African ancestry have much greater
genetic diversity than do other populations. African– American populations
exhibit twice the prevalence of type 2 diabetes as compared with their ... Cited by 14 - Related articles - BL Direct - All 5 versions
SC Elbein, H Zheng, Y Jia, W Chu, JJ Cooper, … - Molecular Genetics and Metabolism, 2004 - Elsevier Increased glucose metabolism through the hexosamine pathway may result in
insulin resistance, impaired insulin secretion, and diabetic nephropathy. We
hypothesized that variants of GFPT1 encoding ... Cited by 7 - Related articles - All 3 versions
CJ Gallagher, CJ Gordon, CD Langefeld, JC … - Molecular Genetics and Metabolism, 2006 - Elsevier African Americans (AA) are at increased risk for developing type 2 diabetes
mellitus (T2DM) relative to European Americans. We previously detected linkage
of T2DM to 6q24-q27 (LOD 2.26) at 163.5 cM, closest to marker D6S1035, in a ... Cited by 8 - Related articles - All 3 versions
