S Georgia, A Bhushan - Diabetes, 2006 - Am Diabetes Assoc Diabetes results from an inadequate mass of functional β-cells. Such inadequacy
could result from loss of β-cells due to an immune assault or the inability to
compensate for insulin resistance. Thus, mechanisms that regulate the ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by
the ß-cells of the pancreatic islet. Accordingly, strategies that lead to
increased pancreatic ß-cell mass, as well as retained or enhanced function ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►nih.gov L Zhong, S Georgia, S Tschen, K Nakayama, … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig Diabetes results from an inadequate mass of functional β cells, due to either
β cell loss caused by immune assault or the lack of compensation to overcome
insulin resistance. Elucidating the mechanisms that regulate β cell mass ... Cited by 11 - Related articles - BL Direct - All 7 versions
JJ Heit, SK Karnik, SK Kim, 2006 - Annual Reviews Abstract Once thought incapable of significant proliferation, the pancreatic
β-cell has recently been shown to harbor immense powers of self-renewal.
Pancreatic β-cells, the sole source of insulin in vertebrate animals, can ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►endojournals.org H Zhang, AM Ackermann, GA Gusarova, D … - Molecular Endocrinology, 2006 - Endocrine Soc The FoxM1 transcription factor is highly expressed in proliferating cells and
activates several cell cycle genes, although its requirement appears to be
limited to certain tissue types. Embryonic hepatoblast-specific ... Cited by 20 - Related articles - BL Direct - All 4 versions
T Uchida, T Nakamura, N Hashimoto, T … - Nature medicine, 2005 - whitelabs.org The protein p27Kip1 regulates cell cycle progression in mammals by inhibiting
the activity of cyclin-dependent kinases (CDKs). Here we show that p27Kip1
progressively accumulates in the nucleus of pancreatic beta cells in mice ... Cited by 84 - Related articles - All 8 versions
I Cozar-Castellano, M Weinstock, M Haught… - Diabetes, 2006 - ncbi.nlm.nih.gov We hypothesized that combined transgenic overexpression of hepatocyte growth
factor (HGF) and placental lactogen in islets would lead to even greater
increases in beta-cell mass and replication than either growth factor ... Cited by 22 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org RC Vasavada, I Cozar-Castellano, D Sipula, … - Diabetes, 2007 - Am Diabetes Assoc Animal studies show that G 1/S regulatory molecules (D-cyclins, cdk-4, p18, p21,
p27) are critical for normal regulation of β-cell proliferation, mass, and
function. The retinoblastoma protein, pRb, is positioned at the very end of ... Cited by 12 - Related articles - BL Direct - All 5 versions
RC Vasavada, JA Gonzalez-Pertusa, Y … - International Journal of Biochemistry and Cell Biology, 2006 - Elsevier Recent studies have demonstrated that human islet allograft transplantation can
be a successful therapeutic option in the treatment of patients with Type I
diabetes. However, this impressive recent advance is accompanied by a very ... Cited by 38 - Related articles - All 4 versions
S Georgia, R Soliz, M Li, P Zhang, A Bhushan - Developmental biology, 2006 - Elsevier In developing organs, the regulation of cell proliferation and cell cycle exit
is coordinated. How this coordination is achieved, however, is not clear. We
show that the cyclin kinase inhibitor p57 regulates cell cycle exit of ... Cited by 33 - Related articles - All 4 versions
