- ►diabetesjournals.org JC Koster, MS Remedi, R Masia, B Patton, A Tong, CG … - Diabetes, 2006 - Am Diabetes Assoc Glucose metabolism in pancreatic β-cells elevates cytoplasmic [ATP]/[ADP], causing closure
of ATP-sensitive K + channels (K ATP channels), Ca 2+ entry through voltage-dependent Ca
2+ channels, and insulin release. Decreased responsiveness of K ATP channels to the ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►adisonline.com [PDF] BF Palmer - American Journal of Cardiovascular Drugs, 2008 - ingentaconnect.com Most hypertensive patients will require more than one antihypertensive drug to lower BP below
target levels. Abstract The combination of diuretics with renin-angiotensin system (RAS) antagonists
offers several advantages to include additive BP-lowering efficacy and enhanced ... Cited by 4 - Related articles - BL Direct - All 6 versions
- ►turkiyeklinikleri.com [PDF] JI Barzilay, JA Cutler, BR Davis - Current opinion in nephrology and …, 2007 - journals.lww.com Purpose of review Over the past decade post-hoc analyses of clinical trials and observational
studies have tended to show that participants treated with thiazide diuretics are at greater risk
for newly diagnosed diabetes mellitus than those treated with other medication classes. ... Cited by 7 - Related articles - BL Direct - All 14 versions
FM Ashcroft - Am J Physiol, 2007 - 万方数据资源系统 This essay is based on a lecture given to the American Physiological Society in honor of Walter
B. Cannon, an advocate of homeostasis. It focuses on the role of the ATP-sensitive potassium
K(+) (K(ATP)) channel in glucose homeostasis and, in particular, on its role in insulin ... Cited by 8 - Related articles - All 2 versions
CA Girard, FT Wunderlich, K Shimomura, S … - The Journal of Clinical …, 2009 - ukpmc.ac.uk Neonatal diabetes is a rare monogenic form of diabetes that usually presents within the first six
months of life. It is commonly caused by gain-of-function mutations in the genes encoding the
Kir6.2 and SUR1 subunits of the plasmalemmal ATP-sensitive K + (K ATP ) channel. To ... Related articles
- ►cell.com JC Koster, HT Kurata, D Enkvetchakul, CG Nichols - Biophysical Journal, 2008 - Elsevier ATP-sensitive K + -channels link metabolism and excitability in neurons, myocytes, and pancreatic
islets. Mutations in the pore-forming subunit (Kir6.2; KCNJ11) cause neonatal diabetes, developmental
delay, and epilepsy by decreasing sensitivity to ATP inhibition and suppressing electrical ... Related articles - All 7 versions
G Reboldi, G Gentile, F Angeli, P … - Vascular Health and …, 2009 - pubmedcentral.nih.gov The diabetes epidemic continues to grow unabated, with a staggering toll in micro- and macrovascular
complications, disability, and death. Diabetes causes a two- to fourfold increase in the risk of
cardiovascular disease, and represents the first cause of dialysis treatment both in the UK ... Cited by 1 - Related articles - All 6 versions
- ►oxfordjournals.org P Proks, C Girard, FM Ashcroft - Human Molecular Genetics, 2005 - Oxford Univ Press Recent studies have shown that heterozygous mutations in KCNJ11, which encodes Kir6.2, the
pore-forming subunit of the ATP-sensitive potassium (K ATP ) channel, cause permanent neonatal
diabetes either alone (R201C, R201H) or in association with developmental delay, ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org JC Koster, MS Remedi, C Dao, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc The prediction that overactivity of the pancreatic ATP-sensitive K + channel (K ATP channel)
underlies reduced insulin secretion and causes a diabetic phenotype in humans has recently
been borne out by genetic studies implicating "activating" mutations in the Kir6.2 subunit ... Cited by 34 - Related articles - BL Direct - All 5 versions
BF Palmer, ASA Naderi - Journal of the American Society of Hypertension, 2007 - Elsevier Thaizides are effective agents in lowering blood pressure when used as monotherapy and they
provide additive blood pressure lowering effects when combined with many other antihypertensive
drugs. The seventh Joint National Committee report recommends thiazide diuretics as ... Cited by 1 - Related articles - All 3 versions
