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Scholar Results 1 - 10 of about 101 related to Szabó: Poly (ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic.... (0.09 sec) 

Poly (ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/ …

- diabetesjournals.org
C Szabó, A Biser, R Benkő, E Böttinger, K … - Diabetes, 2006 - Am Diabetes Assoc
The activation of the poly(ADP-ribose) polymerase (PARP) plays an important role
in the pathophysiology of various diseases associated with oxidative stress. We
found increased amounts of poly(ADP) ribosylated proteins in diabetic ...
Cited by 35 - Related articles - BL Direct - All 6 versions

Effects of poly (ADP-ribose) polymerase inhibition on dysfunction of non-adrenergic non- …


TM Gibson, MA Cotter, NE Cameron - Nitric Oxide, 2006 - Elsevier
Diabetes mellitus compromises nitric oxide (NO)-mediated endothelium-dependent
relaxation of blood vessels, which has been linked to the excessive generation
of reactive oxygen species. There are also deleterious effect on nitrergic ...
Cited by 8 - Related articles - All 3 versions

Poly (ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory …

- nih.gov
O Ilnytska, VV Lyzogubov, MJ Stevens, VR … - Diabetes, 2006 - Am Diabetes Assoc
Poly(ADP-ribose) polymerase (PARP) activation is emerging as a fundamental
mechanism in the pathogenesis of diabetes complications including diabetic
neuropathy. This study evaluated the role of PARP in diabetic sensory ...
Cited by 26 - Related articles - BL Direct - All 10 versions

Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice

- academia.edu [PDF] 
I Vareniuk, IA Pavlov, VR Drel, VV Lyzogubov, … - Experimental Neurology, 2007 - Elsevier
Nitrosative stress contributes to nerve conduction slowing, thermal hypoalgesia,
and impaired nitrergic innervation in animal models of Type 1 diabetes. The role
for reactive nitrogen species in Type 2 diabetes-associated neuropathy ...
Cited by 19 - Related articles - All 5 versions

Oxidative-Nitrosative Stress and Poly (ADP-Ribose) Polymerase (PARP) Activation in …

- nih.gov
IG Obrosova, VR Drel, P Pacher, O Ilnytska, … - Diabetes, 2005 - Am Diabetes Assoc
Poly(ADP-ribose) polymerase (PARP) activation, an important factor in the
pathogenesis of diabetes complications, is considered a downstream effector of
oxidative-nitrosative stress. However, some recent findings suggest that it ...
Cited by 37 - Related articles - BL Direct - All 11 versions

Role of poly (ADP-ribose) polymerase activation in diabetic neuropathy


IG Obrosova, F Li, OI Abatan, MA Forsell, K … - Diabetes, 2004 - Am Diabetes Assoc
Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic
neuropathy, but the mechanisms remain unidentified. Here we provide evidence
that poly(ADP-ribose) polymerase (PARP) activation, a downstream effector ...
Cited by 87 - Related articles - BL Direct - All 10 versions

Effects of the peroxynitrite decomposition catalyst, FeTMPyP, on function of corpus …


MR Nangle, MA Cotter, NE Cameron - European journal of pharmacology, 2004 - Elsevier
Peroxynitrite, the reaction product of nitric oxide and superoxide, may
contribute to vascular tissue oxidant stress in diabetes mellitus. The aim was
to establish whether the peroxynitrite decomposition catalyst 5,10,15,20- ...
Cited by 24 - Related articles - All 4 versions

PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and …


IG Obrosova, W Xu, VV Lyzogubov, O Ilnytska, … - Free Radical Biology and Medicine, 2008 - Elsevier
Evidence that poly(ADP-ribose) polymerase (PARP) activation plays an important
role in diabetic complications is emerging. This study evaluated the role of
PARP in rat and mouse models of advanced diabetic neuropathy. The orally ...
Cited by 15 - Related articles - All 3 versions

Evaluation of orally active poly (ADP-ribose) polymerase inhibitor in streptozotocin-diabetic …

- inotekcorp.com [PDF] 
F Li, C Szabo, P Pacher, GJ Southan, OI … - Diabetologia, 2004 - Springer
Aims/hypothesis. Poly(ADP-ribose) polymerase acti- vation depletes NAD + and
high-energy phosphates, activates protein kinase C, and affects gene expression
in various tissues. This study was designed to charac- terise the effects ...
Cited by 38 - Related articles - BL Direct - All 11 versions

Evaluation of the peroxynitrite decomposition catalyst Fe (III) tetra-mesitylporphyrin …


VR Drel, P Pacher, I Vareniuk, IA Pavlov, O … - International journal of molecular medicine, 2007 - pubmedcentral.nih.gov
Whereas the important role of free radicals in diabetes-associated complications
is well established, the contributions of the highly reactive oxidant
peroxynitrite have not been properly explored. The present study used a ...
Cited by 9 - Related articles - BL Direct - All 4 versions


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