- ►diabetesjournals.org NE Standifer, Q Ouyang, C Panagiotopoulos, CB … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-lymphocytes (CTLs) are considered to be essential for β-cell destruction in type 1
diabetes. However, few islet-associated peptides have been demonstrated to activate autoreactive
CTLs from type 1 diabetic subjects. ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org Q Ouyang, NE Standifer, H Qin, P Gottlieb, CB … - Diabetes, 2006 - Am Diabetes Assoc Type 1 diabetes results from the autoimmune destruction of insulin-producing pancreatic β-cells by
cytotoxic T-lymphocytes (CTLs). In humans, few β-cell epitopes have been reported, thereby limiting
the study of β-cell–specific ... Cited by 37 - Related articles - BL Direct - All 4 versions
A Toma, S Haddouk, JP Briand, L … - Proceedings of the …, 2005 - National Acad Sciences Proinsulin is a key autoantigen in type 1 diabetes. Evidence in the mouse has underscored the
importance of the insulin B chain region in autoimmunity to pancreatic beta cells. In man, a
majority of proteasome cleavage ... Cited by 56 - Related articles - BL Direct - All 8 versions
Y Hassainya, F Garcia-Pons, R Kratzer, V Lindo, F … - Diabetes, 2005 - Am Diabetes Assoc Type 1 diabetes is thought to result from the destruction of β-cells by autoantigen-specific
T-cells. Observations in the NOD mouse model suggest that CD8 + cytotoxic T-cells play an essential
role in both the initial triggering ... Cited by 43 - Related articles - All 6 versions
- ►jimmunol.org T Takaki, MP Marron, CE Mathews, ST … - The Journal of …, 2006 - Am Assoc Immnol In both humans and NOD mice, particular MHC genes are primary contributors to development of the
autoreactive CD4 + and CD8 + T cell responses against pancreatic cells that cause type 1 diabetes
(T1D). Association studies have ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Mallone, E Martinuzzi, P Blancou, G Novelli, G … - Diabetes, 2007 - Am Diabetes Assoc Despite the understanding that type 1 diabetes pathogenesis is mediated by T-cells, detection of
these rare lymphocytes remains largely elusive. Suitable T-cell assays are highly needed, since they
could offer preclinical diagnoses ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org P Blancou, R Mallone, E Martinuzzi, S … - The Journal of …, 2007 - Am Assoc Immnol Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic cells. CD8 + T cells
have recently been assigned a major role in cell injury. Consequently, the identification of
autoreactive CD8 + T cells in ... Cited by 10 - Related articles - All 6 versions
NE Standifer, Q Ouyang, C Panagiotopoulos, CB … - 糖尿病学杂志, 2006 - journal.shouxi.net Cytotoxic T-lymphocytes (CTLs) are considered to be essential for -cell destruction in type 1
diabetes. However, few islet-associated peptides have been demonstrated to activate autoreactive
CTLs from type 1 diabetic subjects. ... Related articles - Cached
- ►pnas.org GGM Pinkse, OHM Tysma, CAM Bergen, … - Proceedings of the …, 2005 - National Acad Sciences Type 1 diabetes is a T cell-mediated autoimmune disease, and insulin is an important target of the
autoimmune response associated with β cell destruction. The mechanism of destruction is still
unknown. Here, we provide evidence ... Cited by 88 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org C Panagiotopoulos, H Qin, R Tan, CB Verchere - Diabetes, 2003 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease in which pancreatic β-cells are destroyed by cytotoxic
T-cells that recognize peptide epitopes presented by HLA class I molecules. The identification of
human β-cell epitopes may ... Cited by 49 - Related articles - BL Direct - All 4 versions
