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Scholar Results 1 - 10 of about 101 related to Qi: Loss of resistin improves glucose homeostasis in leptin deficiency. (0.09 sec) 

Loss of resistin improves glucose homeostasis in leptin deficiency

- diabetesjournals.org
Y Qi, Z Nie, YS Lee, NS Singhal, PE Scherer, MA Lazar … - Diabetes, 2006 - Am Diabetes Assoc
Resistin levels are increased in obesity, and hyperresistinemia impairs glucose homeostasis
in rodents. Here, we have determined the role of resistin in ob/ob mice that are obese and insulin
resistant because of genetic deficiency of leptin. Loss of resistin increased obesity in ...
Cited by 42 - Related articles - BL Direct - All 6 versions

Hypothalamic resistin induces hepatic insulin resistance

- nih.gov
ED Muse, TKT Lam, PE Scherer, L … - Journal of Clinical …, 2007 - Am Soc Clin Investig
Circulating resistin stimulates endogenous glucose production (GP). Here, we report that bi-directional
changes in hypothalamic resistin action have dramatic effects on GP and proinflammatory cytokine
expression in the liver. The infusion of either resistin or an active cysteine mutant in the ...
Cited by 34 - Related articles - BL Direct - All 8 versions

Regulation of resistin expression and circulating levels in obesity, diabetes, and …

- pubget.com [PDF] 
MW Rajala, Y Qi, HR Patel, N Takahashi, R Banerjee, … - Diabetes, 2004 - Am Diabetes Assoc
Resistin was originally reported as an adipose tissue–specific hormone that provided a link between
obesity and diabetes. Resistin protein level was elevated in obese mice and decreased by
insulin-sensitizing thiazolidinediones. Immunoneutralization of resistin improved insulin ...
Cited by 117 - Related articles - BL Direct - All 5 versions

Abnormal glucose homeostasis due to chronic hyperresistinemia

- diabetesjournals.org
SM Rangwala, AS Rich, B Rhoades, JS Shapiro, S … - Diabetes, 2004 - Am Diabetes Assoc
Resistin is an adipocyte-secreted protein that circulates at increased levels in obesity. Acute
administration of resistin impairs glucose tolerance, but the effects of chronic hyperresistinemia
have not been established. Here we describe the generation and characterization of ...
Cited by 121 - Related articles - BL Direct - All 4 versions

A novel aminosterol reverses diabetes and fatty liver disease in obese mice

- genaera.com [PDF] 
N Takahashi, Y Qi, HR Patel, RS Ahima - Journal of hepatology, 2004 - Elsevier
1436 decreased body weight, specifically fat content, by inhibiting food intake and increasing
energy expenditure. In contrast to weight loss from food restriction, this aminosterol specifically
lowered circulating lipids, reversed hepatic steatosis and normalized alanine ...
Cited by 16 - Related articles - All 7 versions

Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin …

- nih.gov
H Satoh, MTA Nguyen, PDG Miles, T … - Journal of Clinical …, 2004 - Am Soc Clin Investig
We investigated the chronic in vivo effect of resistin on insulin sensitivity and glucose metabolism
by overexpressing resistin protein in male Wistar rats using intravenous administration of an
adenovirus encoding mouse resistin. After 7 days of elevated resistin levels at a ...
Cited by 159 - Related articles - BL Direct - All 7 versions

Role of resistin in diet-induced hepatic insulin resistance

- nih.gov
ED Muse, S Obici, S Bhanot, BP Monia, RA … - Journal of Clinical …, 2004 - Am Soc Clin Investig
Resistin is an adipose-derived hormone postulated to link adiposity to insulin resistance. To
determine whether resistin plays a causative role in the development of diet-induced insulin
resistance, we lowered circulating resistin levels in mice by use of a specific antisense ...
Cited by 193 - Related articles - BL Direct - All 10 versions

[PDF] Role of resistin in inflammation and inflammation-related diseases


SS Pang, YY Le - Immunology, 2006 - cmi.ustc.edu.cn
Resistin is a newly identified adipocyte secreted hormone belonging to a cysteine-rich protein
family. It is expressed in white adipose tissues in rodents and has also been found in several
other tissues in human. Insulin, glucose, many cytokines and anti-diabetic ...
Cited by 42 - Related articles - View as HTML - All 3 versions

Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by …


R Palanivel, G Sweeney - FEBS letters, 2005 - Elsevier
Resistin has been proposed as a potential link between obesity and insulin resistance. It is also
well established that altered metabolism of fatty acids by skeletal muscle can lead to insulin resistance
and lipotoxicity. However, little is known about the effect of resistin on long chain fatty acid ...
Cited by 59 - Related articles - All 4 versions

Regulation of insulin signalling, glucose uptake and metabolism in rat skeletal …


R Palanivel, A Maida, Y Liu, G Sweeney - Diabetologia, 2006 - Springer
Abstract Aims/hypothesis: Debate exists regarding the role of resistin in the pathophysiology
of insulin resistance. The aim of this study was to directly assess the effects of resistin (0–24
h) on basal and insulin-stimulated glucose uptake and metabolism in skeletal muscle ...
Cited by 39 - Related articles - BL Direct - All 3 versions


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