Y Ohshiro, RC Ma, Y Yasuda, J Hiraoka-Yamamoto, … - Diabetes, 2006 - Am Diabetes Assoc Diabetes induces the activation of several protein kinase C (PKC) isoforms in the renal
glomeruli. We used PKC-β −/− mice to examine the action of PKC-β isoforms in diabetes-induced
oxidative stress and renal injury at 8 and 24 weeks of disease. Diabetes increased PKC ... Cited by 38 - Related articles - BL Direct - All 6 versions
M Meier, JK Park, D Overheu, T Kirsch, C Lindschau, F … - Diabetes, 2007 - Am Diabetes Assoc The protein kinase C (PKC)-β isoform has been implicated to play a pivotal role in the development
of diabetic kidney disease. We tested this hypothesis by inducing diabetic nephropathy in
PKC-β–deficient (PKC-β −/− ) mice. We studied nondiabetic and streptozotocin-induced ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org V Thallas-Bonke, SR Thorpe, MT Coughlan, K Fukami, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Apocynin attenuated diabetes-associated increases in albuminuria and
glomerulosclerosis. Circulating, renal cytosolic, and skin collagen–associated AGE levels in
diabetic rats were not reduced by apocynin. Diabetes-induced translocation of PKC, ... Cited by 27 - Related articles - BL Direct - All 4 versions
J Menne, M Meier, JK Park, M Boehne, T Kirsch, C … - Kidney international, 2006 - nature.com Albuminuria in diabetic nephropathy is due to endothelial dysfunction, a loss of negative charges
in the basement membrane, and changes a of the slit-membrane diaphragm composition. We
have recently shown that protein kinase C alpha (PKC )-deficient mice are protected ... Cited by 22 - Related articles - BL Direct - All 6 versions
- ►jbc.org Y Gorin, K Block, J Hernandez, B Bhandari, B … - Journal of Biological …, 2005 - ASBMB Renal hypertrophy and extracellular matrix accumulation are early features of diabetic
nephropathy. We investigated the role of the NAD(P)H oxidase Nox4 in generation of reactive
oxygen species (ROS), hypertrophy, and fibronectin expression in a rat model of type 1 ... Cited by 93 - Related articles - BL Direct - All 5 versions
K Asaba, A Tojo, ML Onozato, A Goto, MT QUINN, T … - Kidney international, 2005 - nature.com Received 27 July 2004; Revised 7 November 2004; Accepted 19 November 2004. ... Effects
of NADPH oxidase inhibitor in diabetic nephropathy. ... We used apocynin to test the hypothesis
that superoxide anion (O - 2 ) from nicotinamide adenine dinucleotide phosphate ... Cited by 80 - Related articles - All 4 versions
T Etoh, T Inoguchi, M Kakimoto, N Sonoda, K … - Diabetologia, 2003 - Springer Aim/hypothesis. An increased production of reactive oxygen species (ROS) could contribute
to the devel- opment of diabetic nephropathy. NAD(P)H oxidase might be an important source
of ROS production in kidney as reported in blood vessels. In this study, we show the ... Cited by 79 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org J Menne, JK Park, M Boehne, M Elger, C Lindschau, T … - Diabetes, 2004 - Am Diabetes Assoc Activation of protein kinase C (PKC) isoforms has been implicated in the pathogenesis of diabetic
nephropathy. We showed earlier that PKC-α is activated in the kidneys of hyperglycemic
animals. We now used PKC-α −/− mice to test the hypothesis that this PKC isoform ... Cited by 52 - Related articles - BL Direct - All 4 versions
