- ►diabetesjournals.org MN Weedon, B Shields, G Hitman, M Walker, … - Diabetes, 2006 - Am Diabetes Assoc Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) is an inhibitor
of insulin-induced activation of the insulin receptor. There is strong evidence
from several previous studies that a common coding variant of ENPP1 (K121Q) ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org HN Lyon, JC Florez, T Bersaglieri, R Saxena, … - Diabetes, 2006 - Am Diabetes Assoc The common missense single nucleotide polymorphism (SNP) K121Q in the ectoenzyme
nucleotide pyrophosphate phosphodiesterase (ENPP1) gene has recently been
associated with type 2 diabetes in Italian, US, and South-Asian ... Cited by 48 - Related articles - BL Direct - All 7 versions
- ►pubget.com [PDF] N Grarup, SA Urhammer, J Ek, A Albrechtsen, … - Diabetologia, 2006 - Springer Page 1. ARTICLE Studies of the relationship between the ENPP1 K121Q polymorphism
and type 2 diabetes, insulin resistance and obesity ... Cited by 41 - Related articles - BL Direct - All 5 versions
- ►endojournals.org Y Bottcher, A Korner, T Reinehr, B Enigk, W … - Journal of Clinical Endocrinology & Metabolism, 2006 - Endocrine Soc Results: We identified a significantly increased risk of obesity in Leipzig
children carrying the 121Q variant (adjusted odds ratio, 1.82; 95% confidence
interval, 1.30–2.56; P = 0.0005) or the [Q-delT-G] haplotype [1.75 ... Cited by 34 - Related articles - All 6 versions
- ►diabetesjournals.org J Bochenski, G Placha, K Wanic, M Malecki, J … - Diabetes, 2006 - Am Diabetes Assoc The K121Q polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1
(ENPP1) is associated with type 2 diabetes and obesity. The possibility of other
ENPP1 polymorphisms influencing these phenotypes has received little ... Cited by 35 - Related articles - BL Direct - All 6 versions
N Matsuoka, A Patki, HK Tiwari, DB Allison, … - International Journal of Obesity, 2005 - nature.com To test for association of the ectonucleotide pyrophosphatase/phosphodiesterase
1 (ENPP1) K121Q polymorphism with body mass index (BMI) and diabetes in a large
sample of Caucasians and African-Americans by selectively genotyping ... Cited by 40 - Related articles - BL Direct - All 4 versions
D Meyre, N Bouatia-Naji, V Vatin, J Veslot, C … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis We assessed the predictive value of ectonu- cleotide
pyrophosphatase/phosphodiesterase 1 gene (ENPP1) SNPs with regard to the risk of
developing obesity and/or type 2 diabetes in a large French general ... Cited by 20 - Related articles - BL Direct - All 3 versions
- ►shouxi.net N Abate, M Chandalia, P Satija, B Adams- … - Diabetes, 2005 - Am Diabetes Assoc Genetic susceptibility modulates the impact of obesity on risk for type 2
diabetes. The present study evaluates the role of ENPP1 K121Q polymorphism in
prediction of type 2 diabetes in three populations that differ in ... Cited by 74 - Related articles - All 9 versions
D Meyre, N Bouatia-Naji, A Tounian, C Samson, … - Nature genetics, 2005 - pubmedcentral.nih.gov We identified a childhood obesity locus on chromosome 6q16.3-q24.2 1 that
includes 2.4 Mb common to eight genome scans for Type 2 diabetes (T2D) or
obesity 1 - 8 . Analysis of the ENPP1 (PC-1) gene, a candidate for insulin ... Cited by 161 - Related articles - BL Direct - All 10 versions
- ►tokushima-u.ac.jp [PDF] P Keshavarz, H Inoue, Y Sakamoto, K Kunika, … - Journal of Human Genetics, 2006 - Springer Abstract Ecto-nucleotide pyrophosphatase/phosphodi- esterase 1 (ENPP1, also
known as PC-1) inhibits insulin signal transduction pathway(s). Previous studies
have demonstrated the K121Q variant of the ENPP1 gene to have a significant ... Cited by 29 - Related articles - BL Direct - All 9 versions
