- ►shouxi.net CW Hay, K Docherty - Diabetes, 2006 - Am Diabetes Assoc DNA sequences that regulate expression of the insulin gene are located within a
region spanning ∼400 bp that flank the transcription start site. This region,
the insulin promoter, contains a number of cis-acting elements that bind ... Cited by 31 - Related articles - BL Direct - All 9 versions
CW Hay, K Docherty - DIABETES, 2006 - Am Diabetes Assoc T he cloning and sequencing of the insulin gene in 1980 (1) was a landmark
breakthrough that opened up a new field of research on the mech- anisms
controlling expression of the gene. This in turn led to the discovery of ... Related articles
HM Docherty, CW Hay, LA Ferguson, J Barrow … - Biochemical Journal, 2005 - pubmedcentral.nih.gov The insulin promoter binds a number of tissue-specific and ubiquitous
transcription factors. Of these, the homoeodomain protein PDX-1 (pancreatic
duodenal homeobox factor-1), the basic leucine zipper protein MafA and the ... Cited by 30 - Related articles - BL Direct - All 8 versions
- ►jbc.org J Francis, SK Chakrabarti, JC Garmey, RG … - Journal of Biological Chemistry, 2005 - ASBMB Expression of the insulin gene is nearly exclusive to the cells of the
pancreatic islets. Although the sequence-specific transcription factors that
regulate insulin expression have been well studied, the interrelationship ... Cited by 32 - Related articles - BL Direct - All 6 versions
WG Jang, EJ Kim, KG Park, YB Park, HS Choi, … - Biochemical and biophysical research communications, 2007 - Elsevier Transcriptional regulation of the insulin gene plays a critical role in
maintenance of pancreatic beta cell function in response to various stimuli.
Here, we used INS-1 cells to test the hypothesis that PGC-1α regulates ... Cited by 7 - Related articles - All 7 versions
- ►pnas.org P Bertolino, R Holmberg, E Reissmann, O … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences All major cell types in pancreatic islets express the transforming growth factor
(TGF)-β superfamily receptor ALK7, but the physiological function of this
receptor has been unknown. Mutant mice lacking ALK7 showed normal pancreas ... Cited by 8 - Related articles - BL Direct - All 7 versions
J Francis, DA Babu, TG Deering, SK … - Molecular Endocrinology, 2006 - Endocrine Soc The pancreatic and duodenal homeobox factor 1 (Pdx-1) is a Hox-like
transcription factor that is responsible for the activation of the insulin gene.
Previous studies have demonstrated the interaction in vitro of Pdx-1 with ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org C Evans-Molina, JC Garmey, R Ketchum, KL … - Diabetes, 2007 - Am Diabetes Assoc Glucose is the primary regulator of insulin granule release from pancreatic
islets. In rodent islets, the role of glucose in the acute regulation of insulin
gene transcription has remained unclear, primarily because the abundance ... Cited by 9 - Related articles - BL Direct - All 6 versions
- ►cell.com M Gannon - Cell metabolism, 2007 - Elsevier Type 2 diabetes results from combined insulin resistance in peripheral
insulin-responsive tissues (liver, muscle, and fat) and decreased functional β
cell mass. In normal β cells, glucose metabolism leads to increased ... Cited by 4 - Related articles - All 10 versions
AR Clark, ME Wilson, I Leibiger, V Scott, K … - European Journal of Biochemistry, 1995 - interscience.wiley.com A negative regulatory element (NRE) is located between positions −279 and
−261 relative to the transcription start site of the human insulin gene. The
NRE contains at least three distinct overlapping binding sites for several ... Cited by 19 - Related articles - BL Direct - All 4 versions
