- ►diabetesjournals.org E Nascimento, M Fodor, G van der Zon, IM Jazet, A … - Diabetes, 2006 - Am Diabetes Assoc Clinical insulin resistance is associated with decreased activation of phosphatidylinositol
3′-kinase (PI3K) and its downstream substrate protein kinase B (PKB)/Akt. However, its physiological
protein substrates remain poorly characterized. In the present study, the effect of in vivo ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] JE Harthill, MP Rubio, FC Milne, C … - Biochemical …, 2002 - pubmedcentral.nih.gov Unstimulated PC12 pheochromocytoma cells contain many proteins that bound to 14-3-3s in
competition with a 14-3-3- binding peptide. Additional proteins, including one of 39 kDa
(p39), became capable of binding to 14-3-3s in phosphatidyl- inositol ... Cited by 17 - Related articles - BL Direct - All 10 versions
- ►ahajournals.org A Saito, T Hayashi, S Okuno, T Nishi, PH Chan - Stroke, 2006 - Am Heart Assoc Background and Purpose— A proline-rich Akt substrate (PRAS) contributes to the regulation
of apoptosis after a variety of cell death stimuli, as well as in an in vivo transient focal cerebral
ischemia (tFCI) model. We reported previously that overexpression of copper/zinc- ... Cited by 7 - Related articles - All 6 versions
B Huang, G Porter - Acta Pharmacologica Sinica, 2005 - chinaphar.com Kovacina et al used a combination of the 14-3-3 protein and anti-pAkt substrate antibodies to
screen and isolate a substrate of Akt, the major 14-3-3 binding protein observed in cells after
insulin treatment (a 40 kDa molecule) [8] . This protein contains a consensus Akt ... Cited by 17 - Related articles - Cached - BL Direct - All 8 versions
- ►biologists.org A Singh, X Shi, KW Choi - Development, 2006 - dev.biologists.org Organogenesis involves an initial surge of cell proliferation, leading to differentiation. This is
followed by cell death in order to remove extra cells. During early development, there is little
or no cell death. However, there is a lack of information concerning the genes required for ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►jneurosci.org A Saito, P Narasimhan, T Hayashi, S Okuno, M … - Journal of …, 2004 - Soc Neuroscience The Akt signaling pathway contributes to regulation of apoptosis after a variety of cell death
stimuli. A novel proline-rich Akt substrate (PRAS) was recently detected and found to be involved
in apoptosis. In our study, Akt activation was modulated by growth factors, and treatment ... Cited by 57 - Related articles - BL Direct - All 5 versions
- ►aacrjournals.org SRV Madhunapantula, A Sharma, GP Robertson - Cancer Research, 2007 - AACR Despite many clinical trials in melanoma testing a wide variety of nontargeted therapeutic approaches
involving immunotherapy, radiotherapy, and chemotherapy, no effective long-term treatment
has been identified for advanced-stage patients (1–3). This has led to the realization that ... Cited by 19 - Related articles - BL Direct - All 3 versions
L Wang, CJ Rhodes, JC Lawrence - Journal of Biological Chemistry, 2006 - ASBMB Insulin stimulates protein synthesis by promoting phosphorylation of the eIF4E-binding
protein, 4EBP1. This effect is rapamycin-sensitive and mediated by mammalian target of rapamycin
(mTOR) complex 1 (mTORC1), a signaling complex containing mTOR, raptor, and ... Cited by 23 - Related articles - All 6 versions
- ►jbc.org KS Kovacina, GY Park, SS Bae, AW Guzzetta, E … - Journal of Biological …, 2003 - ASBMB Akt (also called protein kinase B) is one of the major downstream targets of the phosphatidylinositol
3-kinase pathway. This protein kinase has been implicated in insulin signaling, stimulation of
cellular growth, and inhibition of apoptosis as well as transformation of cells. Although a ... Cited by 82 - Related articles - BL Direct - All 4 versions
