- ►shouxi.net E Tweedie, I Artner, L Crawford, G … - Diabetes, 2006 - Am Diabetes Assoc The Onecut homeodomain transcription factor hepatic nuclear factor 6 (Hnf6) is
necessary for proper development of islet β-cells. Hnf6 is initially expressed
throughout the pancreatic epithelium but is downregulated in endocrine ... Cited by 4 - Related articles - BL Direct - All 6 versions
LW Crawford, ET Ables, YA Oh, B Boone, S … - PLoS One, 2008 - pubmedcentral.nih.gov In the past decade, several transcription factors critical for pancreas
organogenesis have been identified. Despite this success, many of the factors
necessary for proper islet morphogenesis and function remain ... Cited by 2 - Related articles - All 5 versions
LA Crawford, MA Guney, YA Oh, RA DeYoung, … - Molecular Endocrinology, 2009 - Endocrine Soc The factors necessary for normal pancreatic islet morphogenesis have not been
well characterized. Here we report that connective tissue growth factor (CTGF)
is involved in the establishment of normal islet endocrine cell ratio and ... Cited by 2 - Related articles - All 3 versions
A Villasenor, DC Chong, O Cleaver - Developmental Dynamics, 2008 - interscience.wiley.com Ngn3 is a bHLH transcription factor critical for the specification of endocrine
cells in the pancreatic Islets of Langerhans. Previous studies in mouse embryos
have reported transient expression of Ngn3 in scattered cells within the ... Cited by 2 - Related articles - All 3 versions
- ►diabetesjournals.org A Fukuda, Y Kawaguchi, K Furuyama, S … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Most pancreatic endocrine cells derive from Ptf1a-expressing
progenitor cells. In humans, nonsense mutations in Ptf1a have recently been
identified as a cause of permanent neonatal diabetes associated with ... Cited by 2 - Related articles - All 4 versions
M Gannon, E Tweedie Ables, L Crawford, D … - Developmental biology, 2008 - Elsevier The pdx1 gene is essential for pancreatic organogenesis in humans and mice; pdx1
mutations have been identified in human diabetic patients. Specific inactivation
of pdx1 in adult β cells revealed that this gene is required for ... Cited by 10 - Related articles - All 4 versions
- ►nih.gov P Dong, E Provost, SD Leach, DYR Stainier - Genes & Development, 2008 - genesdev.cshlp.org The mechanisms regulating pancreatic endocrine versus exocrine fate are not well
defined. By analyzing the effects of Ptf1a partial loss of function, we
uncovered novel roles for this transcription factor in determining ... Cited by 4 - Related articles - BL Direct - All 8 versions
M Öström, KA Loffler, S Edfalk, L Selander, … - PLoS One, 2008 - pubmedcentral.nih.gov The identification of secreted factors that can selectively stimulate the
generation of insulin producing β-cells from stem and/or progenitor cells
represent a significant step in the development of stem cell-based β-cell ... Cited by 4 - Related articles - All 7 versions
- ►nih.gov Y Jiang, W Nishimura, D Devor-Henneman, D … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Selective deletion of survivin in pancreatic endocrine cells in the
mouse had no discernible effects during embryogenesis but was associated with
striking decreases in β-cell number after birth, leading to hyperglycemia ... Cited by 4 - Related articles - All 5 versions
- ►diabetesjournals.org A Misfeldt… - Diabetes, 2008 - Am Diabetes Assoc RESULTS—In control mice, PPx stimulated β-cell proliferation and neogenesis
and upregulated Foxm1 and several of its known targets (Plk1, Cenp-a,
Birc5/Survivin, and Ccnb1) in islets. Within 1 week post-PPx, control mice ... Cited by 4 - Related articles - All 3 versions
