M Peshavaria, BL Larmie, J Lausier, B Satish, … - Diabetes, 2006 - Am Diabetes Assoc The pancreatic β-cell has a substantial capacity to functionally compensate in
response to physiological and pathophysiological changes in tissue insulin
requirements. A fundamental aspect of this response is the dynamic ... Cited by 23 - Related articles - BL Direct - All 5 versions
JJ Meier, JC Lin, AE Butler, R Galasso, DS … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis We investigated whether there was evi- dence of
attempted beta cell regeneration in the pancreas obtained from a patient with
recent-onset type 1 diabetes, and if so by what mechanism this occurred. ... Cited by 53 - Related articles - BL Direct - All 4 versions
BA Menge, H Schrader, TGK Breuer, Y … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Partial pancreatectomy is frequently per- formed in
patients with pancreatic tumours or chronic pancreatitis, but little is known
about the metabolic impact of this intervention. We examined the effects of ... Cited by 3 - Related articles - All 2 versions
BA Menge, A Tannapfel, O Belyaev, R Drescher … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Protocol 1: fasting glucose concentrations increased significantly
after the 50% pancreatectomy (P = 0.01), but the fractional β-cell area of the
pancreas remained unchanged (P = 0.11). β-Cell proliferation, the overall ... Cited by 23 - Related articles - BL Direct - All 5 versions
JJ Meier, LL Kjems, JD Veldhuis, P Lefèbvre, … - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by an ∼60% loss of β-cell mass, a marked
defect in postprandial insulin secretion, and a failure to suppress postprandial
glucagon concentrations. It is possible that postprandial hyperglucagonemia ... Cited by 27 - Related articles - BL Direct - All 9 versions
RA Ritzel, AE Butler, RA Rizza, JD Veldhuis, … - Diabetes Care, 2006 - Am Diabetes Assoc In type 2 diabetes there is a progressive defect of insulin secretion that
precedes the development of hyperglycemia (1). This defect appears to be at
least in part due to a deficit in β-cell mass (2–4). Several therapeutic ... Cited by 41 - Related articles - BL Direct - All 9 versions
J Rahier, Y Guiot, RM Goebbels, C Sempoux, … - Diabetes Obes Metab, 2008 - interscience.wiley.com Decreases in both β-cell function and number can contribute to insulin
deficiency in type 2 diabetes. Here, we quantified the β-cell mass in pancreas
obtained at autopsy of 57 type 2 diabetic (T2D) and 52 non-diabetic ... Cited by 10 - Related articles - All 2 versions
JJ Meier, AE Butler, R Galasso, RA Rizza, PC … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Type 1 and type 2 diabetes are charac- terised by a
beta cell deficit. Islet hyperplasia has been described in patients with
Zollinger–Ellison syndrome secondary to gastrin-producing tumours ... Cited by 21 - Related articles - BL Direct - All 5 versions
AV Matveyenko, JD Veldhuis, PC Butler - Diabetes, 2006 - Am Diabetes Assoc Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) often
coexist and as such represent a potent risk factor for subsequent development of
type 2 diabetes. β-Cell mass is ∼50% deficient in IFG and ∼65% ... Cited by 21 - Related articles - BL Direct - All 6 versions
