- ►shouxi.net YW Asmann, CS Stump, KR Short, JM Coenen- … - Diabetes, 2006 - Am Diabetes Assoc We investigated whether previously reported muscle mitochondrial dysfunction and
altered gene transcript levels in type 2 diabetes might be secondary to abnormal
blood glucose and insulin levels rather than an intrinsic defect of type 2 ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org KS Nair, ML Bigelow, YW Asmann, LS Chow, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— The glucose infusion rates required to maintain identical glucose
levels during the similar insulin infusion rates were substantially lower in
diabetic Indians than in the nondiabetic participants (P < 0.001), and they ... Cited by 30 - Related articles - BL Direct - All 4 versions
- ►nih.gov CS Stump, KR Short, ML Bigelow, JM Schimke … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Mitochondria are the primary site of skeletal muscle fuel metabolism and ATP
production. Although insulin is a major regulator of fuel metabolism, its effect
on mitochondrial ATP production is not known. Here we report increases in ... Cited by 133 - Related articles - BL Direct - All 10 versions
- ►nih.gov R Boushel, E Gnaiger, P Schjerling, M … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Insulin resistance and type 2 diabetes are associated
with mitochondrial dysfunction. The aim of the present study was to test the
hypothesis that oxidative phosphorylation and electron transport capacity ... Cited by 79 - Related articles - BL Direct - All 9 versions
- ►pubget.com [PDF] VB Schrauwen-Hinderling, ME Kooi, MKC … - Diabetologia, 2007 - Springer Page 1. ARTICLE Impaired in vivo mitochondrial function but similar
intramyocellular lipid content in patients with type 2 diabetes ... Cited by 41 - Related articles - BL Direct - All 5 versions
A Wredenberg, C Freyer, ME Sandström, A … - Biochemical and Biophysical Research …, 2006 - Elsevier Insulin resistance in skeletal muscle is a characteristic feature of diabetes
mellitus type 2 (DM2). Several lines of circumstantial evidence suggest that
reduced mitochondrial oxidative phosphorylation capacity in skeletal muscle ... Cited by 22 - Related articles - All 5 versions
J Szendroedi, AI Schmid, M Chmelik, C Toth, … - PLoS Med, 2007 - medicine.plosjournals.org We measured G-6-P, ATP synthetic flux (ie, synthesis) and lipid contents of
skeletal muscle with 31 P/ 1 H magnetic resonance spectroscopy in ten patients
with T2DM and in two control groups: ten sex-, age-, and body mass-matched ... Cited by 40 - Related articles - Cached - All 9 versions
- ►shouxi.net M Mogensen, K Sahlin, M Fernström, D … - Diabetes, 2007 - Am Diabetes Assoc We tested the hypothesis of a lower respiratory capacity per mitochondrion in
skeletal muscle of type 2 diabetic patients compared with obese subjects. Muscle
biopsies obtained from 10 obese type 2 diabetic and 8 obese nondiabetic ... Cited by 50 - Related articles - BL Direct - All 6 versions
- ►pnas.org KR Short, ML Bigelow, J Kahl, R Singh, J … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Cumulative mtDNA damage occurs in aging animals, and mtDNA mutations are
reported to accelerate aging in mice. We determined whether aging results in
increased DNA oxidative damage and reduced mtDNA abundance and ... Cited by 109 - Related articles - All 11 versions
C Bonnard, A Durand, S Peyrol, E Chanseaume … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov Mitochondrial dysfunction in skeletal muscle has been implicated in the
development of type 2 diabetes. However, whether these changes are a cause or a
consequence of insulin resistance is not clear. We investigated the ... Cited by 51 - Related articles - BL Direct - All 8 versions
