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Scholar Results 1 - 10 of about 101 related to Drel: The Leptin-Deficient (ob/ob) Mouse. (0.58 sec) 

The Leptin-Deficient (ob/ob) Mouse

- diabetesjournals.org
VR Drel, N Mashtalir, O Ilnytska, J Shin, F Li … - Diabetes, 2006 - Am Diabetes Assoc
Whereas functional, metabolic, neurotrophic, and morphological abnormalities of
peripheral diabetic neuropathy (PDN) have been extensively explored in
streptozotocin-induced diabetic rats and mice (models of type 1 diabetes), ...
Cited by 31 - Related articles - BL Direct - All 7 versions

Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice

- academia.edu [PDF] 
I Vareniuk, IA Pavlov, VR Drel, VV Lyzogubov, … - Experimental Neurology, 2007 - Elsevier
Nitrosative stress contributes to nerve conduction slowing, thermal hypoalgesia,
and impaired nitrergic innervation in animal models of Type 1 diabetes. The role
for reactive nitrogen species in Type 2 diabetes-associated neuropathy ...
Cited by 19 - Related articles - All 5 versions

Poly (ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory …

- nih.gov
O Ilnytska, VV Lyzogubov, MJ Stevens, VR … - Diabetes, 2006 - Am Diabetes Assoc
Poly(ADP-ribose) polymerase (PARP) activation is emerging as a fundamental
mechanism in the pathogenesis of diabetes complications including diabetic
neuropathy. This study evaluated the role of PARP in diabetic sensory ...
Cited by 26 - Related articles - BL Direct - All 10 versions

Neurotrophic modulation of myelinated cutaneous innervation and mechanical sensory loss …

- nih.gov
JA Christianson, JM Ryals, MS Johnson, RT … - Neuroscience, 2007 - Elsevier
Human diabetic patients often lose touch and vibratory sensations, but to date,
most studies on diabetes-induced sensory nerve degeneration have focused on
epidermal C-fibers. Here, we explored the effects of diabetes on cutaneous ...
Cited by 16 - Related articles - All 5 versions

High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity

- shouxi.net
IG Obrosova, O Ilnytska, VV Lyzogubov, IA … - Diabetes, 2007 - Am Diabetes Assoc
RESULTS—HFD-fed mice developed obesity, increased plasma FFA and insulin
concentrations, and impaired glucose tolerance. They also had motor and sensory
nerve conduction deficits, tactile allodynia, and thermal hypoalgesia in ...
Cited by 20 - Related articles - BL Direct - All 6 versions

Progression of vascular and neural dysfunction in sciatic nerves of Zucker diabetic fatty and …

- physiology.org
CL Oltman, LJ Coppey, JS Gellett, EP … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc
We have examined the progression of vascular and neural deficits in Zucker rats,
Zucker diabetic fatty (ZDF) diabetic rats, and age-matched lean ZDF rats from 8
to 40 wk of age. Both the ZDF diabetic and Zucker rats were glucose ...
Cited by 28 - Related articles - BL Direct - All 4 versions

Aldose Reductase–Deficient Mice Are Protected From Delayed Motor Nerve Conduction …

- shouxi.net
E Ho, KSL Lam, YS Chen, JCW Yip, M … - Diabetes, 2006 - Am Diabetes Assoc
The exaggerated flux through polyol pathway during diabetes is thought to be a
major cause of lesions in the peripheral nerves. Here, we used aldose reductase
(AR)-deficient (AR −/− ) and AR inhibitor (ARI)-treated mice to further ...
Cited by 30 - Related articles - BL Direct - All 7 versions

Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite …

- fasebj.org [PDF] 
IG Obrosova, JG Mabley, Z Zsengeller, T … - The FASEB Journal, 2004 - FASEB
Page 1. ©2004 FASEB The FASEB Journal express article10.1096/fj.04-1913fje.
Published online December 20, 2004. Role for nitrosative ...
Cited by 58 - Related articles - All 6 versions

Remote neurotrophic support of epidermal nerve fibres in experimental diabetes


C Toth, V Brussee, DW Zochodne - Diabetologia, 2006 - Springer
Abstract Aims/hypothesis: The support of distal regen- erating axons and
epidermal nerve fibres through growth factor delivery may depend on the site of
delivery. While low-dose systemic insulin provides trophic support for ...
Cited by 25 - Related articles - BL Direct - All 3 versions

A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin- …


VR Drel, P Pacher, I Vareniuk, I Pavlov, O … - European journal of pharmacology, 2007 - pubmedcentral.nih.gov
Whereas an important role of free radicals and oxidants in peripheral diabetic
neuropathy is well established, the contribution of nitrosative stress and, in
particular, of the highly reactive oxidant peroxynitrite, has not been ...
Cited by 13 - Related articles - All 6 versions


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