- ►diabetesjournals.org J Gray, GSH Yeo, JJ Cox, J Morton, ALR Adlam, JM … - Diabetes, 2006 - Am Diabetes Assoc The neurotrophin brain-derived neurotrophic factor (BDNF) inhibits food intake, and rodent models
of BDNF disruption all exhibit increased food intake and obesity, as well as hyperactivity. We
report an 8-year-old girl with hyperphagia and severe obesity, impaired cognitive ... Cited by 55 - Related articles - BL Direct - All 7 versions
GSH Yeo, CCC Hung, J Rochford, J Keogh, J Gray, S … - Nature neuroscience, 2004 - nature.com An 8-year-old male with a complex developmental syndrome and severe obesity was heterozygous
for a de novo missense mutation resulting in a Y722C substitution in the neurotrophin receptor
TrkB. This mutation markedly impaired receptor autophosphorylation and signaling to ... Cited by 102 - Related articles - BL Direct - All 4 versions
J Gray, G Yeo, C Hung, J Keogh, P Clayton, K … - International Journal of …, 2006 - nature.com The neurotrophin receptor TrkB has been implicated in the regulation of energy homeostasis
in rodents. We have previously identified four rare missense mutations in the gene encoding
TrkB, NTRK2, in 198 severely obese children with developmental delay. We have now ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org IS Farooqi, S Drop, A Clements, JM Keogh, J Biernacka … - Diabetes, 2006 - Am Diabetes Assoc Congenital deficiency of proopiomelanocortin (POMC) results in a syndrome of
hypoadrenalism, severe obesity, and altered skin and hair pigmentation. The concept that subtle
variation in POMC expression and/or function might contribute to common obesity is ... Cited by 38 - Related articles - BL Direct - All 6 versions
- ►jneurosci.org TJ Unger, GA Calderon, LC Bradley, M Sena- … - Journal of …, 2007 - Soc Neuroscience Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are expressed in several hypothalamic
and hindbrain nuclei involved in regulating energy homeostasis, developmentally and in the
adult animal. Their depletion during the fetal or early postnatal periods when ... Cited by 25 - Related articles - All 3 versions
- ►nih.gov IS Farooqi, T Wangensteen, S Collins, W … - The New England …, 2007 - nejm.highwire.org I. Sadaf Farooqi, MB, BS, Ph.D., Teresia Wangensteen, MD, Stephan Collins, Ph.D., Wendy
Kimber, Ph.D., Giuseppe Matarese, MD, Ph.D., Julia M. Keogh, B.Sc., Emma Lank, B.Sc., Bill
Bottomley, Ph.D., Judith Lopez-Fernandez, MD, Ph.D., Ivan Ferraz-Amaro, MD, Ph.D., ... Cited by 94 - Related articles - BL Direct - All 14 versions
- ►cell.com YS Lee, BG Challis, DA Thompson, GSH Yeo, JM … - Cell Metabolism, 2006 - Elsevier The melanocortin-4 receptor (MC4R) plays a critical role in the control of energy balance. Of
its two pro-opiomelanocortin (POMC)-derived ligands, α- and β-MSH, the majority of attention
has focused on α-MSH, partly reflecting the absence of β-MSH in rodents. We screened ... Cited by 53 - Related articles - All 12 versions
- ►endojournals.org IS Farooqi, K Volders, R Stanhope, R … - Journal of Clinical …, 2007 - Endocrine Soc Results: In vitro this mutation markedly impairs the catalytic activity of the convertase.
However, in contrast to other previously described naturally occurring mutations, intracellular
trafficking of this mutant enzyme appeared normal. The Ser307Leu mutant retained some ... Cited by 17 - Related articles - BL Direct - All 5 versions
H Biebermann, TR Castañeda, F van Landeghem, A … - Cell Metabolism, 2006 - Elsevier Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive
by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort
has focused on α-melanocyte-stimulating hormone (α-MSH) as the predominant POMC- ... Cited by 52 - Related articles - All 8 versions
