- ►shouxi.net J Xu, WN Lee, J Phan, MF Saad, K Reue, IJ … - Diabetes, 2006 - Am Diabetes Assoc Fatty liver is a common feature of both obesity and lipodystrophy, reflecting
compromised adipose tissue function. The lipin-deficient fatty liver dystrophy
(fld) mouse is an exception, as there is lipodystrophy without a fatty ... Cited by 13 - Related articles - BL Direct - All 7 versions
B Lindegaard, LF Larsen, ABE Hansen, J … - International Journal of Obesity, 2006 - nature.com Lipodystrophy is the major complication of antiretroviral therapy in
HIV-infected patients. Its pathophysiology is not well understood, but has been
linked to antiadipogenic effects of antiretroviral drugs. Lipin represents ... Cited by 16 - Related articles - BL Direct - All 4 versions
- ►angrylapdog.com MA Croce, JC Eagon, LL LaRiviere, KM … - Diabetes, 2007 - diabetes.diabetesjournals.org.p.angrylapdog.com RESULTS— The expression of lipin 1β in liver and adipose tissue was inversely
related to BMI, fasting plasma insulin concentration, and the homeostasis model
assessment of insulin resistance but was significantly increased by marked ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►angrylapdog.com TE Harris, TA Huffman, A Chi, J Shabanowitz … - Journal of Biological Chemistry, 2007 - jbc.org.p.angrylapdog.com Brain, liver, kidney, heart, and skeletal muscle from fatty liver dystrophy
(fld/fld) mice, which do not express lipin 1 (lipin), contained much less Mg 2+
-dependent phosphatidic acid phosphatase (PAP) activity than tissues from ... Cited by 34 - Related articles - All 8 versions
- ►oxfordjournals.org E Suviolahti, K Reue, RM Cantor, J Phan, M … - Human Molecular Genetics, 2006 - Oxford Univ Press Recent studies in the mouse have demonstrated that variations in lipin
expression levels in adipose tissue have marked effects on adipose tissue mass
and insulin sensitivity. In the mouse, lipin deficiency prevents normal ... Cited by 43 - Related articles - BL Direct - All 9 versions
- ►endojournals.org J Donkor, LM Sparks, H Xie, SR Smith, K … - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Results: In healthy young men, lipin-1 expression was positively correlated with
insulin sensitivity (R 2 = 0.22; P < 0.01), insulin-stimulated respiratory
quotient (R 2 = 0.16; P < 0.01), and maximal oxygen consumption during ... Cited by 8 - Related articles - BL Direct - All 6 versions
RJF Loos, T Rankinen, L Pérusse, A Tremblay … - Obesity, 2007 - nature.com Results: The strongest results were generation-specific. In parents, RMR of the
G/G IVS13 + 3333A>G homozygotes was 107 kcal/d higher than in A/A homozygotes
and 39 kcal/d higher than in A/G heterozygotes (p = 0.0003). In offspring, ... Cited by 8 - Related articles - All 3 versions
[CITATION] Lipin expression is attenuated in adipose tissue of insulin resistant human subjects and …
- ►nih.gov KA Fawcett, N Grimsey, RJF Loos, E Wheeler, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Loss of lipin 1 activity causes lipodystrophy and insulin
resistance in the fld mouse, and LPIN1 expression and common genetic variation
were recently suggested to influence adiposity and insulin sensitivity in ... Cited by 3 - Related articles - All 6 versions
- ►jbc.org J Donkor, M Sariahmetoglu, J Dewald, DN … - Journal of Biological Chemistry, 2007 - ASBMB We previously identified mutations in the Lpin1 gene, encoding lipin-1, as the
underlying cause of lipodystrophy in the fatty liver dystrophy (fld) mutant
mouse. Lipin-1 is normally expressed at high levels in adipose tissue and ... Cited by 62 - Related articles - All 6 versions
