- ►diabetesjournals.org H Sørensen, MS Winzell, CL Brand, K … - Diabetes, 2006 - Am Diabetes Assoc In previous studies, glucagon receptor knockout mice (Gcgr −/− ) display
reduced blood glucose and increased glucose tolerance, with hyperglucagonemia
and increased levels of glucagon-like peptide (GLP)-1. However, the role of ... Cited by 15 - Related articles - BL Direct - All 3 versions
H Srensen, MS Winzell, CL Brand, K Fosgerau … - 糖尿病学杂志, 2006 - journal.shouxi.net In previous studies, glucagon receptor knockout mice (Gcgr / ) display reduced
blood glucose and increased glucose tolerance, with hyperglucagonemia and
increased levels of glucagon-like peptide (GLP)-1. However, the role of ... Related articles - Cached
SL Conarello, G Jiang, J Mu, Z Li, J Woods, … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Under normal physiological conditions, glucagon
signalling is important in glucose homeostasis. Hyperglucagonaemia or altered
insulin:glucagon ratio plays a role in maintaining hyperglycaemia in ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►glucagon.com [PDF] EM Sinclair, B Yusta, C Streutker, LL Baggio, … - Gastroenterology, 2008 - Elsevier Gcgr−/− mice showed enhanced susceptibility to experimental liver injury
induced by either FasL activation or a methionine- and choline-deficient diet.
Restoration of hepatic Gcgr expression in Gcgr−/− mice attenuated the ... Cited by 3 - Related articles - All 47 versions
- ►physiology.org P Bansal, Q Wang - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Glucose homeostasis is regulated primarily by the opposing actions of insulin
and glucagon, hormones that are secreted by pancreatic islets from β-cells and
-cells, respectively. Insulin secretion is increased in response to ... Cited by 6 - Related articles - All 3 versions
- ►endojournals.org PM Vuguin, MH Kedees, L Cui, Y Guz, RW … - Endocrinology, 2006 - Endocrine Soc Although glucagon (GLU) plays a pivotal role in glucose homeostasis, its role in
the regulation of fetal growth and maturation is poorly understood. These issues
were examined in a line of mice with a global deletion of the GLU receptor ... Cited by 14 - Related articles - BL Direct - All 4 versions
JC Parker, KM Andrews, MR Allen, JL Stock, … - Biochemical and Biophysical Research …, 2002 - Elsevier The action of glucagon in the liver is mediated by G-coupled receptors. To
examine the role of glucagon in glucose homeostasis, we have generated mice in
which the glucagon receptor was inactivated (GR −/− mice). Blood ... Cited by 44 - Related articles - BL Direct - All 6 versions
- ►physiology.org JA Harney, RL Rodgers - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc At concentrations around 10 –9 M or higher, glucagon increases cardiac
contractility by activating adenylate cyclase/cyclic adenosine monophosphate
(AC/cAMP). However, blood levels in vivo, in rats or humans, rarely exceed ... Cited by 2 - Related articles - All 4 versions
RM Kim, J Chang, AR Lins, E Brady, MR … - Bioorganic & medicinal chemistry letters, 2008 - Elsevier Type 2 diabetes is characterized by chronically elevated plasma glucose levels.
A major contributor to this condition is excessive hepatic glucose production
resulting from inappropriately high levels of the hormone glucagon, which ... Cited by 2 - Related articles - All 4 versions
- ►nih.gov KW Sloop, JXC Cao, AM Siesky, HY Zhang, DM … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Uncontrolled hepatic glucose production contributes significantly to
hyperglycemia in patients with type 2 diabetes. Hyperglucagonemia is implicated
in the etiology of this condition; however, effective therapies to block ... Cited by 46 - Related articles - BL Direct - All 6 versions
