- ►diabetesjournals.org CS Lee, DD De León, KH Kaestner, DA … - Diabetes, 2006 - Am Diabetes Assoc Understanding the factors and mechanisms involved in β-cell regeneration will
guide therapeutic efforts to augment β-cell mass in patients with diabetes.
Neurogenin-3 (Ngn3) is a bHLH transcription factor that responds to Notch ... Cited by 34 - Related articles - BL Direct - All 5 versions
- ►daegu.ac.kr [PDF] S Kodama, T Toyonaga, T Kondo, K Matsumoto … - Biochemical and Biophysical Research …, 2005 - Elsevier Progenitor cells exist in the adult pancreas and transform to endocrine cells in
pathological conditions. To address the mechanism of β cell regeneration, mice
were treated with streptozotocin (STZ group) or streptozotocin and ... Cited by 24 - Related articles - All 5 versions
L Baeyens, S Bonne, MS German, P … - Cell Death & Differentiation, 2006 - nature.com The basic helix–loop–helix protein Neurogenin3 specifies precursor cells of
the endocrine pancreas during embryonic development, and is thought to be absent
postnatally. We have studied Ngn3 expression during in vitro generation of ... Cited by 15 - Related articles - BL Direct - All 5 versions
- ►slas.ac.cn [PDF] X Xu, J D'Hoker, G Stange, S Bonné, N De … - Cell, 2008 - Elsevier Novel strategies in diabetes therapy would obviously benefit from the use of
beta (β) cell stem/progenitor cells. However, whether or not adult β cell
progenitors exist is one of the most controversial issues in today's ... Cited by 101 - Related articles - All 9 versions
- ►nih.gov T Nir, DA Melton, Y Dor - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The mechanisms that regulate pancreatic β cell mass are poorly understood.
While autoimmune and pharmacological destruction of insulin-producing β cells
is often irreversible, adult β cell mass does fluctuate in response to ... Cited by 101 - Related articles - BL Direct - All 8 versions
CS Lee, DD De León, KH Kaestner, DA … - DIABETES, 2006 - Am Diabetes Assoc Neurogenin3 (ngn3), a basic helix-loop-helix (bHLH) transcription factor,
functions as a pro-endocrine factor in the developing pancreas: by itself, it is
sufficient to force undifferentiated pancreatic epithelial cells to be- ... Related articles - All 2 versions
- ►unipune.ernet.in [PDF] MV Joglekar, VS Parekh, S Mehta, RR Bhonde … - Developmental Biology, 2007 - Elsevier The mammalian pancreas is known to show a remarkable degree of regenerative
ability. Several studies until now have demonstrated that the mammalian pancreas
can regenerate in normal as well as diabetic conditions. These studies ... Cited by 20 - Related articles - All 3 versions
S De Breuck, L Baeyens, L Bouwens - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: It was recently reported that culturing adult exocrine
cells in the presence of epidermal growth factor and leukaemia inhibitory factor
(LIF) re- sulted in their transdifferentiation into endocrine beta cells. ... Cited by 9 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org AM Holland, LJ Góñez, G Naselli, RJ … - Diabetes, 2005 - Am Diabetes Assoc The homeodomain transcription factor Pdx1 is essential for pancreas development.
To investigate the role of Pdx1 in the adult pancreas, we employed a mouse model
in which transcription of Pdx1 could be reversibly repressed by ... Cited by 38 - Related articles - BL Direct - All 5 versions
- ►shouxi.net M Peshavaria, BL Larmie, J Lausier, B Satish, … - Diabetes, 2006 - Am Diabetes Assoc The pancreatic β-cell has a substantial capacity to functionally compensate in
response to physiological and pathophysiological changes in tissue insulin
requirements. A fundamental aspect of this response is the dynamic ... Cited by 23 - Related articles - BL Direct - All 5 versions
