- ►diabetesjournals.org I Artner, J Le Lay, Y Hang, L Elghazi, JC Schisler, E … - Diabetes, 2006 - Am Diabetes Assoc The large Maf family of basic leucine-zipper–containing transcription factors are known regulators
of key developmental and functional processes in various cell types, including pancreatic
islets. Here, we demonstrate that within the adult pancreas, MafB is only expressed in ... Cited by 37 - Related articles - BL Direct - All 7 versions
- ►nih.gov W Nishimura, T Kondo, T Salameh, I El Khattabi, R … - Developmental biology, 2006 - Elsevier Major insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally important roles
in pancreatic development and the differentiation of pancreatic endocrine cells. Previously, we
identified and cloned another critical insulin gene transcription factor MafA (RIPE3b1) and ... Cited by 50 - Related articles - All 7 versions
T Matsuoka, I Artner, E Henderson, A … - Proceedings of the …, 2004 - National Acad Sciences Insulin gene expression is regulated by several islet-enriched transcription factors. However,
MafA is the only β cell-specific activator. Here, we show that MafA selectively induces endogenous
insulin transcription in non-β cells. MafA was also first detected in the insulin-producing ... Cited by 84 - Related articles - BL Direct - All 10 versions
- ►nih.gov C Zhang, T Moriguchi, M Kajihara, R Esaki, A … - Molecular and Cellular …, 2005 - Am Soc Microbiol MafA is a transcription factor that binds to the promoter in the insulin gene and has been postulated
to regulate insulin transcription in response to serum glucose levels, but there is no current in
vivo evidence to support this hypothesis. To analyze the role of MafA in insulin ... Cited by 77 - Related articles - All 8 versions
I Artner, B Blanchi, JC Raum, M Guo, T … - Proceedings of the …, 2007 - National Acad Sciences Pancreatic endocrine cell differentiation depends on transcription factors that also contribute
in adult insulin and glucagon gene expression. Islet cell development was examined in mice
lacking MafB, a transcription factor expressed in immature α (glucagon + ) and β (insulin + ... Cited by 21 - Related articles - BL Direct - All 7 versions
- ►nih.gov T Matsuoka, L Zhao, I Artner, HW Jarrett, D … - Molecular and Cellular …, 2003 - Am Soc Microbiol The C1/RIPE3b1 (-118/-107 bp) binding factor regulates pancreatic-ß-cell-specific and
glucose-regulated transcription of the insulin gene. In the present study, the C1/RIPE3b1 activator
from mouse ßTC-3 cell nuclear extracts was purified by DNA affinity chromatography and ... Cited by 117 - Related articles - BL Direct - All 6 versions
- ►pubget.com [PDF] JC Raum, K Gerrish, I Artner, E Henderson, M … - Molecular and cellular …, 2006 - Am Soc Microbiol The MafA transcription factor is both critical to islet ß-cell function and has a unique pancreatic
cell-type-specific expression pattern. To localize the potential transcriptional regulatory
region(s) involved in directing expression to the ß cell, areas of identity within the 5' ... Cited by 21 - Related articles - BL Direct - All 5 versions
R Ashery-Padan, X Zhou, T Marquardt, P Herrera, L … - Developmental Biology, 2004 - Elsevier Pax6 transcription factor is required for islet cell number, morphology, and hormone gene
expression. The perinatal lethality of Pax6 null mutants has restricted investigation of the role
of Pax6 in normal endocrine cell function. Therefore, we devised the conditional ... Cited by 45 - Related articles - All 3 versions
M Olbrot, J Rud, LG Moss, A … - Proceedings of the …, 2002 - National Acad Sciences Of the three critical enhancer elements that mediate β-cell-specific and glucose-responsive expression
of the insulin gene, only the identity of the transcription factor binding to the RIPE3b element
(RIPE3b1) has remained elusive. Using a biochemical purification approach, we have ... Cited by 147 - Related articles - BL Direct - All 8 versions
R Scott Heller, DA Stoffers, A Liu, A Schedl, EB … - Developmental Biology, 2004 - Elsevier Brain 4 (Brn4/Pou3f4) and Pax6 are POU-homeodomain and paired-homeodomain transcription
factors, respectively, that are expressed in the brain and the glucagon-expressing cells in the
pancreas. Brn4 expression begins at embryonic day 10 in the pancreas, just before pax6 ... Cited by 24 - Related articles - All 3 versions
