- ►diabetesjournals.org S Fatrai, L Elghazi, N Balcazar, C Cras-Méneur, I Krits, … - Diabetes, 2006 - Am Diabetes Assoc Proliferation is the major component for maintenance of β-cell mass in adult animals. Activation of
phosphoinositide 3-kinase/Akt-kinase pathway is a critical regulator of β-cell mass. Pancreatic
β-cell overexpression of ... Cited by 42 - Related articles - BL Direct - All 5 versions
I Cozar-Castellano, M Weinstock, M Haught… - Diabetes, 2006 - ncbi.nlm.nih.gov We hypothesized that combined transgenic overexpression of hepatocyte growth factor (HGF) and
placental lactogen in islets would lead to even greater increases in beta-cell mass and replication
than either growth factor alone. ... Cited by 22 - Related articles - BL Direct - All 2 versions
- ►nih.gov JA Kushner, MA Ciemerych, E Sicinska, LM … - Molecular and Cellular …, 2005 - Am Soc Microbiol Regulation of adult ß-cell mass in pancreatic islets is essential to preserve sufficient insulin
secretion in order to appropriately regulate glucose homeostasis. In many tissues mitogens influence
development by stimulating D-type ... Cited by 115 - Related articles - All 7 versions
- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA Bigatel, … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by the ß-cells of the
pancreatic islet. Accordingly, strategies that lead to increased pancreatic ß-cell mass, as well as
retained or enhanced function of ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org I Cozar-Castellano, KK Takane, R Bottino, AN … - Diabetes, 2004 - Am Diabetes Assoc The major regulator of the gap-1/synthesis phase (G 1 /S) cell cycle checkpoint is the
retinoblastoma protein (pRb), and this is regulated in part by the activities of cyclin-dependent
kinase (cdk)-4 and the D cyclins. ... Cited by 57 - Related articles - BL Direct - All 4 versions
X Zhang, JP Gaspard, Y Mizukami, J Li, F Graeme- … - Diabetes, 2005 - Am Diabetes Assoc Cyclin D1 can stimulate proliferation by driving cells from the G1 into the S-phase of the mammalian
cell cycle. Previous animal studies have implicated the G1-S transition as a key regulatory
checkpoint governing the ... Cited by 32 - Related articles - All 5 versions
- ►diabetesjournals.org RC Vasavada, I Cozar-Castellano, D Sipula, AF … - Diabetes, 2007 - Am Diabetes Assoc Animal studies show that G 1/S regulatory molecules (D-cyclins, cdk-4, p18, p21, p27) are critical
for normal regulation of β-cell proliferation, mass, and function. The retinoblastoma protein, pRb,
is positioned at the very end of a ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] S Georgia, A Bhushan - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig The endocrine pancreas undergoes major remodeling during neonatal development when replication of
differentiated β cells is the major mechanism by which β cell mass is regulated. The molecular
mechanisms that govern the ... Cited by 166 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org I Cozar-Castellano, M Haught, AF Stewart - Diabetes, 2006 - Am Diabetes Assoc The rate of pancreatic β-cell replication is extremely slow. For example, Finegood et al. (1)
report that 3% of rodent β-cells replicate every 24 h. Kushner and colleagues (2) have recently
reported that in older mice, this ... Cited by 11 - Related articles - BL Direct - All 5 versions
RC Vasavada, JA Gonzalez-Pertusa, Y Fujinaka, N … - International Journal of …, 2006 - Elsevier Recent studies have demonstrated that human islet allograft transplantation can be a successful
therapeutic option in the treatment of patients with Type I diabetes. However, this impressive
recent advance is accompanied by a ... Cited by 38 - Related articles - All 4 versions
