- ►shouxi.net R Inagi, Y Yamamoto, M Nangaku, N Usuda, H … - Diabetes, 2006 - Am Diabetes Assoc Many factors are involved in the pathogenesis of diabetic nephropathy. A single
gene abnormality may be prerequisite but insufficient to the disease to
manifest. It is therefore only when a second or sometimes a third damage is ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org M Nangaku, Y Izuhara, N Usuda, R Inagi, T … - Nephrology Dialysis Transplantation, 2005 - ERA-EDTA Results. A low calorie diet for 22 weeks significantly improves obesity,
proteinuria and renal morphological alterations. The correction of renal injury
is independent of blood pressure control. Obesity correction, although ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] T Miyata, M Nangaku, D Suzuki, R Inagi, K … - Journal of Clinical Investigation, 1998 - pubmedcentral.nih.gov Mesangial cells play an important role in maintaining a structure and function
of the glomerulus and in the patho- genesis of glomerular diseases. To identify
a specific gene expressed in human mesangial cells, we used a rapid large- ... Cited by 64 - Related articles - BL Direct - All 7 versions
- ►nih.gov T Miyata, R Inagi, M Nangaku, T Imasawa, M … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Mesangial cells maintain normal glomerular function by mediating ECM remodeling
and immune complex disposal. We have recently identified megsin, a novel member
of the serine protease inhibitor (serpin) superfamily predominantly ... Cited by 45 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org KM Myint, Y Yamamoto, T Doi, I Kato, A … - Diabetes, 2006 - Am Diabetes Assoc Diabetic nephropathy is a major microvascular complication in long-standing
diabetic patients who eventually undergo renal dialysis or transplantation. To
prevent development of this disease and to improve advanced kidney injury, ... Cited by 35 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org R Inagi, Y Izuhara, N Tominaga, M Nangaku, … - Nephrology Dialysis Transplantation, 2007 - ERA-EDTA Results. Megsin ELISA specifically detected megsin but not other serpins. The
detection limit was 0.04 ng/ml, which allowed detection of urinary megsin in
3.6% of healthy individuals. The antigenic epitope in the urine detected by ... Cited by 1 - Related articles - BL Direct - All 3 versions
S Ohtomo, M Nangaku, Y Izuhara, N Yamada, T …, 2008 - nature.com In diabetic nephropathy decreased activities of matrix metalloproteinase
(MMP)-2, MMP-9 and plasmin contribute to mesangial matrix accumulation. Megsin,
a novel member of the serine protease inhibitor superfamily, is ... Cited by 2 - Related articles - All 5 versions
JM Teiken, JL Audettey, DI Laturnus, S … - The Anatomical Record Part B: The New Anatomist - interscience.wiley.com Recent studies show that podocyte nuclear density (N V ) and numbers of renal
podocytes per glomerulus (N) are altered in experimental and spontaneous
diabetes mellitus. N V and N are generally reduced, and it has been ... Cited by 2 - Related articles - BL Direct - All 2 versions
R Inagi, T Miyata, D Suzuki, M Toyoda, T … - Biochemical and Biophysical Research …, 2001 - Elsevier Mesangial cells play critical roles in maintaining a structure and function of
the glomerulus. We previously cloned a novel mesangium-predominant gene, megsin,
a new serine protease inhibitor. To clarify localization and roles of ... Cited by 20 - Related articles - BL Direct - All 4 versions
KC Sourris, JM Forbes - Current Drug Targets, 2009 - ingentaconnect.com Abstract: Diabetes, is a metabolic disorder characterised by chronic
hyperglycaemia, hypertension, dyslipidaemia, micro- albuminuria and
inflammation. Moreover, there are a number of complications associated with ... Cited by 3 - Related articles - All 2 versions
