- ►diabetesjournals.org KY Chu, T Lau, PO Carlsson, PS Leung - Diabetes, 2006 - Am Diabetes Assoc We identified an angiotensin-generating system in pancreatic islets and found
that exogenously administered angiotensin II, after binding to its receptors
(angiotensin II type 1 receptor [AT1R]), inhibits insulin release in a ... Cited by 55 - Related articles - BL Direct - All 9 versions
T Lau, PO Carlsson, PS Leung - Diabetologia, 2004 - Springer Aims/hypothesis. A local angiotensin-generating system has been found in the
exocrine pancreas. This study aimed, primarily, to investigate the existence of
a local angiotensin-generating system in the pancreatic islets and, ... Cited by 71 - Related articles - BL Direct - All 9 versions
J Shao, N Iwashita, F Ikeda, T Ogihara, T … - Biochemical and biophysical research communications, 2006 - Elsevier Several epidemiological studies suggested that treatment with angiotensin II
type 1 receptor blocker (ARB) provided a risk reduction of developing type 2
diabetes. In this study, we investigated whether and how ARB treatment can ... Cited by 31 - Related articles - All 6 versions
- ►eje-online.org R Lupi, SD Guerra, M Bugliani, U Boggi, F … - European journal of endocrinology, 2006 - EFES Results: Angiotensinogen, ACE and angiotensin type 1 receptor mRNA expression
increased in islets cultured in high glucose; this was similarly prevented by
the presence of either ACE inhibitor. As expected, preculture of human ... Cited by 33 - Related articles - BL Direct - All 10 versions
KY Chu, PS Leung - Antioxidants & Redox Signaling, 2007 - liebertonline.com G IVEN THAT TYPE 2 diabetes mellitus (T2DM) accounts for >90% of cases of
diabetes and its financial drain on healthcare resources, we are in great need
of alternative ap- proaches to its prevention and treatment. Between 60% ... Cited by 22 - Related articles - BL Direct - All 4 versions
C Tikellis, PJ Wookey, R Candido, S … - Diabetes, 2004 - Am Diabetes Assoc The renin-angiotensin system (RAS) has an important role in the endocrine
pancreas. Although angiotensin II has significant effects on cell proliferation
and apoptosis, the contribution of the RAS to changes in islet structure ... Cited by 118 - Related articles - BL Direct - All 6 versions
M Nakayama, T Inoguchi, T Sonta, Y Maeda, … - Biochemical and Biophysical Research …, 2005 - Elsevier This study was undertaken to reveal the role of NAD(P)H oxidase in increased
oxidative stress in islets of Type 2 diabetes. Immunostaining analysis showed
that staining intensities of NAD(P)H oxidase components, gp91phox and ... Cited by 40 - Related articles - All 6 versions
PS Leung, PO Carlsson - Pancreas, 2005 - journals.lww.com Supported by the Mainline Research Scheme from the Chinese University of Hong
Kong (MR00/008) and partially by the Research Grants Council of Hong Kong (CUHK
4075/00M, CUHK 4116/01M, and CUHK4364/04M), the Swedish Research Council ... Cited by 38 - Related articles - All 6 versions
- ►nih.gov PS Leung - The Journal of Physiology, 2007 - Physiological Soc The systemic renin–angiotensin system (RAS) plays an important role in
regulating blood pressure, electrolyte and fluid homeostasis. However, local
RASs also exist in diverse tissues and organs, where they play a multitude ... Cited by 33 - Related articles - BL Direct - All 11 versions
