- ►shouxi.net JC Henquin, M Nenquin, P Stiernet, B Ahren - Diabetes, 2006 - Am Diabetes Assoc The mechanisms underlying biphasic insulin secretion have not been completely
elucidated. We compared the pattern of plasma insulin changes during
hyperglycemic clamps in mice to that of glucose-induced insulin secretion ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►physiology.org … , DH Wasserman, OP McGuinness, IR Sweet, … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Islets in most species respond to increased glucose with biphasic insulin
secretion, marked by a sharp first-phase peak and a slowly rising second phase.
Mouse islets in vitro, however, lack a robust second phase. To date, this ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►physiology.org R Bertram, A Sherman, LS Satin - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc Impairment of insulin secretion from the -cells of the pancreatic islets of
Langerhans is central to the development of type 2 diabetes mellitus and has
therefore been the subject of much investigation. Great advances have been ... Cited by 18 - Related articles - BL Direct - All 7 versions
- ►psu.edu [PDF] CS Nunemaker, M Zhang, DH Wasserman, OP … - Diabetes, 2005 - Am Diabetes Assoc Pulsatile insulin secretion in vivo is believed to be derived, in part, from the
intrinsic glucose-dependent intracellular calcium concentration ([Ca 2+ ] i )
pulsatility of individual islets. In isolation, islets display fast, slow, ... Cited by 24 - Related articles - BL Direct - All 10 versions
- ►nih.gov CS Nunemaker, R Bertram, A Sherman, K … - Biophysical journal, 2006 - Elsevier Pancreatic islets of Langerhans display complex intracellular calcium changes in
response to glucose that include fast (seconds), slow ( 5 min), and mixed
fast/slow oscillations; the slow and mixed oscillations are likely ... Cited by 16 - Related articles - BL Direct - All 15 versions
D Haspel, P Krippeit-Drews, L Aguilar-Bryan, … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 913–921 DOI 10.1007/s00125-005-1720-8 ARTICLE D.
Haspel . P. Krippeit-Drews . L. Aguilar-Bryan . J. Bryan . G. Drews . ... Cited by 11 - Related articles - All 3 versions
- ►physiology.org N Ishiyama, MA Ravier, JC Henquin - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Glucose induces insulin secretion (IS) and also potentiates the
insulin-releasing action of secretagogues such as arginine and sulfonylureas.
This potentiating effect is known to be impaired in type 2 diabetic ... Cited by 11 - Related articles - BL Direct - All 4 versions
JC Jonas, P Gilon, JC Henquin - Diabetes, 1998 - Am Diabetes Assoc An increase in cytoplasmic Ca 2 + in -cells is a key step in glucose-induced
insulin secretion. However, whether changes in cytoplasmic free Ca 2+ ([Ca 2+ ]
i ) directly regu- late secretion remains disputed. This question was ... Cited by 63 - Related articles - BL Direct - All 4 versions
- ►jbc.org M Nenquin, A Szollosi, L Aguilar-Bryan, J … - Journal of Biological Chemistry, 2004 - ASBMB In normal -cells glucose induces insulin secretion by activating both a
triggering pathway (closure of K ATP channels, depolarization, and rise in
cytosolic [Ca 2+ ] i ) and an amplifying pathway (augmentation of Ca 2+ ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►jbc.org A Szollosi, M Nenquin, JC Henquin - Journal of Biological Chemistry, 2007 - ASBMB A current model ascribes glucose-induced insulin secretion to the interaction of
a triggering pathway (K ATP channel-dependent Ca 2+ influx and rise in cytosolic
[Ca 2+ ] c ) and an amplifying pathway (K ATP channel-independent ... Cited by 14 - Related articles - All 6 versions
