- ►diabetesjournals.org BJ Davis, Z Xie, B Viollet, MH Zou - Diabetes, 2006 - Am Diabetes Assoc Metformin, one of most commonly used drugs for the treatment of type 2 diabetes, improves vascular
endothelial functions and reduces cardiovascular events in patients with type 2 diabetes, although
its mechanisms remain unknown. The current study aimed to elucidate how metformin ... Cited by 92 - Related articles - BL Direct - All 6 versions
VA Morrow, F Foufelle, JMC Connell, JR Petrie, GW … - Journal of Biological …, 2003 - ASBMB Recent studies have indicated that endothelial nitric-oxide synthase (eNOS) is regulated by reversible
phosphorylation in intact endothelial cells. AMP-activated protein kinase (AMPK) has previously
been demonstrated to phosphorylate and activate eNOS at Ser-1177 in vitro, yet the ... Cited by 123 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org Y Hattori, K Suzuki, S Hattori, K Kasai - Hypertension, 2006 - Am Heart Assoc AMP-activated protein kinase (AMPK) is tightly regulated by the cellular AMP:ATP ratio and plays
a central role in regulation of energy homeostasis and metabolic stress. Metformin has been
shown to activate AMPK. We hypothesized that metformin may prevent nuclear factor B ... Cited by 54 - Related articles - All 7 versions
- ►ahajournals.org W Sun, TS Lee, M Zhu, C Gu, Y Wang, Y Zhu, JYJ Shyy - Circulation, 2006 - Am Heart Assoc Methods and Results— Western blotting of protein extracts from human umbilical vein endothelial
cells treated with atorvastatin revealed increased phosphorylation of AMPK at Thr-172 in a
time- and dose-dependent manner. The AMPK activity, assessed by SAMS assay, was ... Cited by 44 - Related articles - All 6 versions
Z Xie, Y Dong, M Zhang, MZ Cui, RA Cohen, U Riek … - Journal of Biological …, 2006 - ASBMB We previously reported the phosphoinositide 3-kinase-dependent activation of the
5′-AMP-activated kinase (AMPK) by peroxynitrite (ONOO - ) and hypoxia-reoxygenation in cultured
endothelial cells. Here we show the molecular mechanism of activation of this pathway. ... Cited by 66 - Related articles - BL Direct - All 5 versions
MH Zou, SS Kirkpatrick, BJ Davis, JS Nelson, WG … - Journal of Biological …, 2004 - ASBMB Metformin, one of the most commonly used drugs for the treatment of type II diabetes, was recently
found to exert its therapeutic effects, at least in part, by activating the AMP-activated protein kinase
(AMPK). However, the site of its action, as well as the mechanism to activate AMPK, ... Cited by 127 - Related articles - BL Direct - All 7 versions
- ►ahajournals.org E Schulz, E Anter, MH Zou, JF Keaney Jr - Circulation, 2005 - Am Heart Assoc Methods and Results— Porcine aortic endothelial cells exhibited time- and concentration-dependent
AMPK activation as determined by phosphorylation of AMPK and its downstream target acetyl
coenzyme A carboxylase in response to estradiol (1 nmol/L to 10 µmol/L, 1 to 30 ... Cited by 57 - Related articles - All 10 versions
MF McCarty - Medical hypotheses, 2005 - Elsevier The endotheliopathy associated with insulin resistance syndrome appears to result largely from
excessive free fatty acid (FFA) exposure that boosts endothelial production of diacylglycerol,
thereby activating protein kinase C. This endothelial “lipotoxicity” can be alleviated by ... Cited by 16 - Related articles - All 22 versions
- ►ahajournals.org Y Zhang, TS Lee, EM Kolb, K Sun, X Lu, FM … - … , and vascular biology, 2006 - Am Heart Assoc Methods and Results— By using flow channels with cultured ECs, AMPK Thr172 phosphorylation
was increased with changes of flow rate or pulsatility. The activity of LKB1, the upstream kinase
of AMPK, and the phosphorylation of eNOS at Ser1179 were concomitant with AMPK ... Cited by 46 - Related articles - All 11 versions
- ►ahajournals.org [PDF] G Ceolotto, A Gallo, I Papparella, L Franco, E … - … , and Vascular Biology, 2007 - Am Heart Assoc Kluwer Health, 351 West Camden Street, Baltimore, MD 21202-2436. Phone:
410-528-4050. Permissions: Permissions & Rights Desk, Lippincott Williams & Wilkins, a division
of Wolters ... Mediated by NAD(P)H Oxidase via ... Giulio Ceolotto, Alessandra Gallo, ... Cited by 30 - Related articles - All 7 versions
