M Lundholm, V Motta, A Löfgren-Burström, N Duarte, … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4), or CD152, is a negative regulator of T-cell
activation and has been shown to be associated with autoimmune diseases. Previous work has
demonstrated a defect in the ... Cited by 8 - Related articles - BL Direct - All 5 versions
N Lineberry, CG Fathman - Immunity, 2006 - Elsevier The adaptive immune system is charged with mounting specific immune responses to antigens derived
from foreign pathogens. Negative selection of immature thymocytes ensures that peripheral T cells
have a low affinity for ... Cited by 3 - Related articles - All 7 versions
- ►jimmunol.org J Irie, B Reck, Y Wu, LS Wicker, S Howlett, D … - The Journal of …, 2008 - Am Assoc Immnol NOD.Idd3/5 congenic mice have insulin-dependent diabetes (Idd) regions on chromosomes 1 (Idd5) and 3
(Idd3) derived from the nondiabetic strains B10 and B6, respectively. NOD.Idd3/5 mice are almost
completely protected from type 1 ... Cited by 5 - Related articles - All 3 versions
CH Grimm*, UC Rogner, P Avner - Autoimmunity, 2003 - informahealthcare.com Three type 1 diabetes associated regions on distal mouse chromosome 6 have recently been defined by
the construction and analysis of a series of congenic strains, carrying C3H/HeJ genomic material on
a NOD/Lt genetic background. Whilst ... Cited by 6 - Related articles - BL Direct - All 6 versions
SE Lamhamedi-Cherradi, O Boulard, C Gonzalez, N … - Diabetes, 2001 - Am Diabetes Assoc The Idd5 locus for autoimmune diabetes in nonobese diabetic (NOD) mice has been mapped to the
proximal half of chromosome 1 and appears to include two loci, Idd5.1 and Idd5.2, Idd5.1 being a
candidate homolog of the human ... Cited by 28 - Related articles - BL Direct - All 4 versions
LS Wicker, CL Moule, H Fraser, C Penha- … - The Genetics of …, 2005 - books.google.com Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse Linda S. Wicker,
Carolyn L. Moule, Heather Fraser, Carlos Penha-Goncalves, Dan Rainbow, Valerie ES Garner, Giselle
Chamberlain, Kara Hunter, Sarah ... Cited by 8 - Related articles - All 4 versions
- ►oxfordjournals.org MS Hung, P Avner, UC Rogner - Human Molecular Genetics, 2006 - Oxford Univ Press The Idd6 murine type 1 diabetes locus has been shown to control diabetes by regulating the
protective activity of the peripheral immune system, as demonstrated by diabetes transfer assays
using splenocytes. The analysis of ... Cited by 8 - Related articles - BL Direct - All 6 versions
M Lundholm - umu.diva-portal.org Type 1 Diabetes (T1D) is an autoimmune disorder caused by both genetic and environmental factors.
The non-obese diabetic (NOD) mouse is one of the best and most commonly studied animal models for
T1D. This mouse strain ... Related articles - View as HTML
P Gao, Y Jiao, Q Xiong, CY Wang, I Gerling, … - Current …, 2008 - pubmedcentral.nih.gov A systematic study has been conducted of all available reports in PubMed and OMIM (Online Mendelian
Inheritance in Man) to examine the genetic and molecular basis of quantitative genetic loci (QTL) of
diabetes with the main focus on ... Related articles - All 4 versions
DS Brown - GSBS Dissertations, 2005 - escholarship.umassmed.edu Page 1. Graduate School of Biomedical Sciences GSBS Dissertations University of Massachusetts
Medical School Year 2005 CD4+ T Cell Responses: A Complex Network of Activating and Tolerizing
Signals as Revealed by Gene Expression Analysis: A Dissertation ... Related articles - All 2 versions
