- ►diabetesjournals.org DJ Michael, RA Ritzel, L Haataja, RH Chow - Diabetes, 2006 - Am Diabetes Assoc Insulin vesicles contain a chemically rich mixture of cargo that includes ions,
small molecules, and proteins. At present, it is unclear if all components of
this cargo escape from the vesicle at the same rate or to the same extent ... Cited by 23 - Related articles - BL Direct - All 6 versions
- ►nih.gov DJ Michael, X Geng, NX Cawley, YP Loh, CJ … - Biophysical Journal, 2004 - Elsevier We compared secretion kinetics for four different fluorescent cargo proteins,
each targeted to the lumen of insulin secretory vesicles. Upon stimulation,
individual vesicles displayed one of four distinct patterns of fluorescence ... Cited by 27 - Related articles - BL Direct - All 8 versions
- ►cell.com DJ Michael, H Cai, W Xiong, J Ouyang, RH … - Trends in Endocrinology & Metabolism, 2006 - Elsevier According to the classical view, peptide hormones are stored in large dense-core
vesicles that release all of their cargo rapidly and completely when they fuse
with and flatten into the plasma membrane. However, recent imaging studies ... Cited by 13 - Related articles - All 4 versions
L Ma, VP Bindokas, A Kuznetsov, C Rhodes, L … - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences Confocal imaging of GFP-tagged secretory granules combined with the use of
impermeant extracellular dyes permits direct observation of insulin packaged in
secretory granules, trafficking of these granules to the plasma membrane, ... Cited by 44 - Related articles - BL Direct - All 9 versions
S Watkins, X Geng, L Li, G Papworth, PD … - Traffic, 2002 - interscience.wiley.com We combined confocal and live-cell imaging with a novel molecular strategy aimed
at revealing mechanisms underlying glucose-regulated insulin vesicle secretion.
The 'Ins-C-GFP' reporter monitors secretory peptide targeting, trafficking, ... Cited by 25 - Related articles - BL Direct - All 3 versions
R Ivarsson, S Obermuller, GA Rutter, J … - Traffic, 2004 - interscience.wiley.com Glucose-evoked insulin secretion exhibits a biphasic time course and is
associated with accelerated intracellular granule movement. We combined live
confocal imaging of EGFP-labelled insulin granules with capacitance ... Cited by 17 - Related articles - BL Direct - All 3 versions
- ►biologists.org S Obermuller, A Lindqvist, J Karanauskaite, … - Journal of Cell Science, 2005 - jcs.biologists.org Secretory granules of insulin-secreting cells are used to store and release
peptide hormones as well as low-molecular-weight compounds such as nucleotides.
Here we have compared the rate of exocytosis with the time courses of ... Cited by 30 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org PE MacDonald, S Obermüller, J Vikman, J … - Diabetes, 2005 - Am Diabetes Assoc We have applied cell-attached capacitance measurements to investigate whether
synaptic-like microvesicles (SLMVs) undergo regulated exocytosis in insulinoma
and primary pancreatic β-cells. SLMV and large dense-core vesicle (LDCV) ... Cited by 33 - Related articles - All 5 versions
Y Man Leung, L Sheu, E Kwan, G Wang, R … - Biochemical and Biophysical Research …, 2002 - Elsevier The examination of insulin exocytosis at the single cell level by conventional
electrophysiologic and amperometric methods possesses inherent limitations, and
may not accurately reflect the morphologic events of exocytosis of the ... Cited by 27 - Related articles - BL Direct - All 7 versions
M Ohara-Imaizumi, S Nagamatsu - Journal of Biochemistry, 2006 - Jpn Biochemical Soc Insulin is stored in pancreatic ß cell granules, and released biphasically by
the exocytotic mechanism induced by nutrient glucose. Insulin exocytosis must be
critically regulated to finely control body glucose homeostasis because ... Cited by 8 - Related articles - All 5 versions
