- ►diabetesjournals.org K Naruse, C Rask-Madsen, N Takahara, S Ha, K … - Diabetes, 2006 - Am Diabetes Assoc Activation of protein kinase C (PKC) in vascular tissue is associated with endothelial dysfunction
and insulin resistance. However, the effect of vascular PKC activation on insulin-stimulated endothelial
nitric oxide (NO) synthase (eNOS) regulation has not been characterized in obesity- ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org XL Wang, L Zhang, K Youker, MX Zhang, J Wang, SA … - Diabetes, 2006 - Am Diabetes Assoc In metabolic syndrome, a systemic deregulation of the insulin pathway leads to a combined deregulation
of insulin-regulated metabolism and cardiovascular functions. Free fatty acids (FFAs), which
are increased in metabolic syndrome, inhibit insulin signaling and induce metabolic ... Cited by 49 - Related articles - BL Direct - All 4 versions
NA Hartell, HE Archer, CJ Bailey - Biochemical pharmacology, 2005 - Elsevier Insulin exerts a vasodilator effect by stimulating endothelial nitric oxide (NO) production. Studies
in cultured cells suggest that insulin might activate endothelial nitric oxide synthase (eNOS) by
an atypical, calcium-independent mechanism. This study investigates the mechanism of ... Cited by 28 - Related articles - All 3 versions
- ►diabetesjournals.org E Arikawa, RCW Ma, K Isshiki, I Luptak, Z He, Y … - Diabetes, 2007 - Am Diabetes Assoc High-density oligonucleotide arrays were used to compare gene expression of rat hearts from
control, untreated diabetic, and diabetic groups treated with islet cell transplantation (ICT), protein
kinase C (PKC)β inhibitor ruboxistaurin, or ACE inhibitor captopril. Among the 376 genes ... Cited by 12 - Related articles - BL Direct - All 5 versions
JB Michel, T Michel - FEBS letters, 1997 - Elsevier Palmitoylation of eNOS is required for targeting to plasmalemmal caveolae and agonist-promoted
depalmitoylation leads to eNOS translocation, modifying the agonist response. To date, one
palmitoyl–protein thioesterase (PPT) has been purified and cloned. To explore the role of ... Cited by 13 - Related articles - All 6 versions
- ►dvdres.com [PDF] I Idris, R Donnelly - Diabetes & Vascular Disease Research, 2006 - dvr.sagepub.com Abstract B iochemical mechanisms involved in hyperglycaemia- induced vascular damage include
alterations in cellular signalling by activation of protein kinase C (PKC). Twelve isoforms of PKC
have been characterised according to their structure and co-factor requirements. ... Cited by 16 - Related articles - BL Direct - All 8 versions
M Matsubara, N Hayashi, T Jing, K Titani - Journal of Biochemistry, 2003 - Jpn Biochemical Soc Endothelial nitric oxide synthase (eNOS) is a key enzyme in nitric oxide–mediated signal transduction
in mammalian cells. Its catalytic activity is regulated both by regulatory proteins, such as calmodulin
and caveolin, and by a variety of post-translational modifications including ... Cited by 52 - Related articles - BL Direct - All 6 versions
FL Marasciulo, M Montagnani, MA … - Current medicinal …, 2006 - ingentaconnect.com Department of Pharmacology and Human Physiology, Medical School – University of Bari,
Bari, Italy Abstract: Endothelin-1 (ET-1) is a vasoconstrictor secreted by endothelial cells, which
acts as the natural counterpart of the vasodilator nitric oxide (NO). ET-1 contributes to ... Cited by 53 - Related articles - BL Direct - All 4 versions
CM Casellini, PM Barlow, AL Rice, M Casey, K … - Diabetes care, 2007 - Am Diabetes Assoc RESULTS—Endothelium-dependent (+78.2%, P < 0.03) and C fiber–mediated (+56.4%, P <
0.03) SkBF at the distal calf increased from baseline to end point. Significant improvements from
baseline within the ruboxistaurin group were also observed for the Neuropathy Total ... Cited by 18 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org C Partovian, Z Zhuang, K Moodie, M Lin, N Ouchi, … - Circulation …, 2005 - Am Heart Assoc Endothelial nitric oxide synthase (eNOS) plays an important role in control of vascular tone and
angiogenesis among other functions. Its regulation is complex and has not been fully
established. Several studies have emphasized the importance of phosphorylation in the ... Cited by 42 - Related articles - All 9 versions
