- ►diabetesjournals.org H Shi, B Cave, K Inouye, C Bjørbæk, JS Flier - Diabetes, 2006 - Am Diabetes Assoc In adipocytes, suppressor of cytokine signaling (SOCS)3 deficiency increases
insulin-stimulated insulin receptor substrate (IRS)-1 and -2 phosphorylation,
IRS-associated phosphatidylinositol 3 kinase activity, and ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►nih.gov Y Jamshidi, H Snieder, X Wang, TD Spector, ND … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: Inhibition of signal transduc- tion by suppressor of
cytokine signalling-3 (SOCS-3) potentially influences resistance to insulin and
leptin. The aim of this study was to test the association between three ... Cited by 11 - Related articles - BL Direct - All 6 versions
F He, JM Stephens - Biochemical and Biophysical Research …, 2006 - Elsevier Insulin receptor substrate (IRS)-1 is a key protein in insulin signaling.
Several studies have shown that the expression of IRS-1 can be modulated by
protein degradation via the proteasome and the degradation of IRS-1 can be ... Cited by 6 - Related articles - All 4 versions
T Gylvin, R Nolsøe, T Hansen, EMD Nielsen, … - Diabetologia, 2004 - Springer Aims/hypothesis. Beta cell loss in Type 1 and Type 2 diabetes mellitus may
result from apoptosis and necrosis induced by inflammatory mediators. The
suppressor of cytokine signalling (SOCS)-3 is a natural inhibitor of ... Cited by 20 - Related articles - BL Direct - All 5 versions
P Lebrun, E Van Obberghen - Acta Physiologica, 2008 - interscience.wiley.com First discovered as inhibitors of cytokine signalling, the suppressor of
cytokine signalling (SOCS) proteins have appeared, over recent years, as potent
repressors of other signalling pathways including the one induced by ... Cited by 12 - Related articles - BL Direct - All 3 versions
H Shi, I Tzameli, C Bjoerbaek, JS Flier - Journal of Biological Chemistry, 2004 - ASBMB Many proinflammatory cytokines and hormones have been demonstrated to be
involved in insulin resistance. However, the molecular mechanisms whereby these
cytokines and hormones inhibit insulin signaling are not completely ... Cited by 92 - Related articles - BL Direct - All 4 versions
R Ni, K Ihara, K Miyako, M Takemoto, M … - International Journal of Immunogenetics, 2006 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 2 - Related articles - BL Direct - All 4 versions
P Kievit, JK Howard, MK Badman, N Balthasar, … - Cell Metabolism, 2006 - Elsevier Suppressor of cytokine signaling-3 (Socs-3) negatively regulates the action of
various cytokines, as well as the metabolic hormones leptin and insulin. Mice
with haploinsufficiency of Socs-3, or those with neuronal deletion of ... Cited by 36 - Related articles - All 8 versions
- ►shouxi.net K Bouzakri, HKR Karlsson, H Vestergaard, S … - Diabetes, 2006 - Am Diabetes Assoc Insulin-dependent diabetic recipients of successful pancreas allografts achieve
self-regulatory insulin secretion and discontinue exogenous insulin therapy;
however, chronic hyperinsulinemia and impaired insulin sensitivity ... Cited by 24 - Related articles - BL Direct - All 5 versions
J Song, HJ Kim, Z Gong, NA Liu, S Lin - Developmental Biology, 2007 - Elsevier Bmp, Fgf, and retinoic acid (RA) signals have been implicated as regulators of
pancreas development. However, the integration of these signaling pathways in
vivo is not fully understood. Variant hnf1 (Vhnf1) is a transcription ... Cited by 9 - Related articles - All 3 versions
