- ►diabetesjournals.org YW Kim, JY Kim, YH Park, SY Park, KC Won, … - Diabetes, 2006 - Am Diabetes Assoc To evaluate whether metformin enhances leptin sensitivity, we measured leptin
sensitivity after 4 weeks of metformin treatment (300 mg/kg daily) in both
standard chow and high-fat–fed obese rats. Anorexic and fat-losing ... Cited by 32 - Related articles - BL Direct - All 6 versions
YW Kim, DW Choi, YH Park, JY Huh, KC Won, … - Regulatory peptides, 2005 - Elsevier To evaluate whether MTII, a melanocortin receptor 3/4 agonist, is working in
hypophagic and hypothermogenic obese model, we measured food intake, body
weight, oxygen consumption, and fat mass following intracerebroventricular ... Cited by 12 - Related articles - All 4 versions
J Rouru, U Pesonen, M Koulu, R Huupponen, E … - European journal of pharmacology, 1995 - Elsevier The hypothalamic neuropeptide Y content and preproneuropeptide Y mRNA expression
were studied in metformin-treated (300 mg/kg orally for 12 days), in pair-fed
and in ad libitum-fed obese Zucker rats in order to elucidate possible ... Cited by 20 - Related articles - All 5 versions
E Keen-Rhinehart, SP Kalra, PS Kalra - Peptides, 2005 - Elsevier Leptin is a hormone secreted primarily by white adipocytes that regulates energy
homeostasis and reproduction via CNS receptors. Koletsky (f/f) rats with a
leptin receptor (OB-Rb) gene mutation are obese, diabetic and infertile. We ... Cited by 16 - Related articles - All 4 versions
- ►endojournals.org C Chau-Van, M Gamba, R Salvi, RC Gaillard, … - Endocrinology, 2007 - Endocrine Soc The oral antidiabetic agent metformin acts at least partially via an activation
of AMP-activated kinase (AMPK) in liver and muscle cells. It has appeared
recently that hypothalamic AMPK is a key regulator of feeding in mammals. ... Cited by 20 - Related articles - BL Direct - All 2 versions
B Fruehwald-Schultes, KM Oltmanns, B … - Metabolism, 2002 - Elsevier A weight-reducing effect of metformin has been demonstrated in obese subjects
with and without diabetes. The mechanisms of this action are unclear, which may
be partly due to the fact that in obese and diabetic patients the ... Cited by 35 - Related articles - BL Direct - All 6 versions
G Li, Y Zhang, JT Wilsey, PJ Scarpace - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Age-related obesity is asso- ciated with impaired
hypothalamic pro-opiomelanocortin (Pomc) gene expression. We assessed whether
overproduc- tion of POMC in the hypothalamus ameliorates age-related ... Cited by 22 - Related articles - BL Direct - All 4 versions
YW Kim, SY Park, JY Kim, JY Huh, WS Jeon, … - Journal of andrology, 2007 - Am Soc Andrology Obesity is a well-known risk factor for erectile dysfunction, which is
associated with reduced penile nitric oxide synthase (NOS) expression. Recently
it was reported that metformin activates AMP-activated protein kinase ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►endocrinology-journals.org J Klein, S Westphal, D Kraus, B Meier, N … - Journal of Endocrinology, 2004 - Soc Endocrinology Metformin is an anti-diabetic drug with anorexigenic properties. The precise
cellular mechanisms of its action are not entirely understood. Adipose tissue
has recently been recognized as an important endocrine organ that is ... Cited by 12 - Related articles - BL Direct - All 8 versions
- ►endojournals.org GR Steinberg, MJ Watt, BC Fam, J Proietto, … - Endocrinology, 2006 - Endocrine Soc We examined the actions of a second-generation ciliary neurotrophic factor
analog (CNTF Ax15 ) on AMP-activated protein kinase (AMPK), a known regulator of
food intake. Unlike leptin CNTF Ax15 has been shown to reduce food intake ... Cited by 28 - Related articles - BL Direct - All 6 versions
