A Corbould, H Zhao, S Mirzoeva, F Aird, A Dunaif - Diabetes, 2006 - Am Diabetes Assoc Insulin resistance in polycystic ovary syndrome (PCOS) results from a postbinding defect in
signaling. Insulin receptor and insulin receptor substrate (IRS)-1 serine hyperphosphorylation
by an unidentified kinase(s) contributes to this defect. We investigated whether insulin ... Cited by 37 - Related articles - BL Direct - All 6 versions
- ►physiology.org A Corbould, YB Kim, JF Youngren, C … - American Journal of …, 2005 - Am Physiological Soc Insulin resistance in polycystic ovary syndrome (PCOS) is due to a postbinding defect in signaling
that persists in cultured skin fibroblasts and is associated with constitutive serine phosphorylation
of the insulin receptor (IR). Cultured skeletal muscle from obese women with PCOS and ... Cited by 63 - Related articles - All 3 versions
- ►physiology.org [PDF] A Corbould, YB Kim, JF Youngren, C … - American Journal of …, 2004 - Am Physiological Soc Page 1. Insulin Resistance in the Skeletal Muscle of Women with Polycystic Ovary Syndrome
Involves both Intrinsic and Acquired Defects in Insulin Signaling Anne Corbould1,
Young-Bum Kim2, Jack F. Youngren3, Celia Pender3, Barbara B. Kahn2, ... Cited by 7 - Related articles
- ►eje.org E Lystedt, H Westergren, J Brynhildsen, L Lindh- … - European Journal of …, 2005 - eje.org Results: The patients with PCOS exhibited marked clinical hyperinsulinemia with 3.6-fold higher
blood levels of C-peptide than a healthy lean control group (1.7 ± 0.2 and 0.5 ± 0.02 nmol/l
respectively, P < 0.0001). The patients with PCOS also exhibited 2.4-fold higher ... Cited by 7 - Related articles - BL Direct - All 7 versions
PJ Marsden, A Murdoch, R Taylor - Metabolism: clinical and …, 1994 - ncbi.nlm.nih.gov Adipose tissue was used to characterize the metabolic abnormality of insulin resistance in polycystic
ovary syndrome (PCOS). Nine patients with PCOS were studied during a period of amenorrhea
and confirmed to be chronically anovulatory by vaginal ultrasound and plasma ... Cited by 40 - Related articles - BL Direct - All 2 versions
- ►endocrinology-journals.org A Corbould - Journal of Endocrinology, 2007 - Soc Endocrinology Adipose tissue plays a central role in determining whole body insulin sensitivity. Several aspects
of adipose cell function are regulated by androgens. Given that high androgen levels and insulin
resistance are linked in women, we proposed that androgens may influence insulin- ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org KM Seow, CC Juan, YP Hsu, JL Hwang, LW Huang, LT … - Human Reproduction, 2007 - ESHRE RESULTS: Before LOE, women with PCOS were found to have significantly higher 2 h
glucose, fasting and 2 h insulin levels, homeostasis model insulin resistance index and lower
fasting glucose-to-insulin ratio (G 0 /I 0 ) than healthy, lean, age-matched controls. Serum ... Cited by 9 - Related articles - BL Direct - All 8 versions
F Gonzalez, NS Rote, J Minium, JP … - Journal of Endocrinology, 2006 - Soc Endocrinology Women with polycystic ovary syndrome (PCOS) are often insulin resistant and have chronic
low-level inflammation. The purpose of this study was to determine the effects of hyperglycemia
in vitro on tumor necrosis factor (TNF)- release from mononuclear cells (MNC) in PCOS. ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►endojournals.org CB Book, A Dunaif - Journal of Clinical Endocrinology & Metabolism, 1999 - Endocrine Soc Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenemia that is amplified
by insulin in the presence of resistance to insulin's action to stimulate glucose uptake in muscle
and fat. To explore the mechanisms for this paradox, we examined the metabolic and ... Cited by 115 - Related articles - BL Direct - All 4 versions
