- ►diabetesjournals.org J Herrington, YP Zhou, RM Bugianesi, PM … - Diabetes, 2006 - Am Diabetes Assoc Delayed-rectifier K + currents (I DR ) in pancreatic β-cells are thought to
contribute to action potential repolarization and thereby modulate insulin
secretion. The voltage-gated K + channel, K V 2.1, is expressed in ... Cited by 27 - Related articles - BL Direct - All 6 versions
- ►nih.gov J Herrington, M Sanchez, D Wunderler, L Yan … - The Journal of Physiology, 2005 - Physiological Soc Voltage-gated potassium (Kv) currents of human pancreatic islet cells were
studied by whole-cell patch clamp recording. On average, 75% of the cells tested
were identified as β-cells by single cell, post-recording RT-PCR for ... Cited by 10 - Related articles - BL Direct - All 8 versions
- ►physiology.org NA Tamarina, A Kuznetsov, LE Fridlyand, LH … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc The delayed-rectifier (voltage-activated) K + conductance (K V ) in pancreatic
islet -cells has been proposed to regulate plasma membrane repolarization during
responses to glucose, thereby determining bursting and Ca 2+ oscillations. ... Cited by 11 - Related articles - BL Direct - All 4 versions
L Yan, DJ Figueroa, CP Austin, Y Liu, RM … - Diabetes, 2004 - Am Diabetes Assoc Voltage-gated potassium channels (Kv channels) are involved in repolarization of
excitable cells. In pancreatic β-cells, prolongation of the action potential by
block of delayed rectifier potassium channels would be expected to increase ... Cited by 37 - Related articles - BL Direct - All 4 versions
J Herrington - Toxicon, 2007 - Elsevier Pancreatic β-cells depolarize in response to glucose and fire calcium-dependent
actions potentials that trigger insulin secretion. The major current responsible
for action potential repolarization in these cells is a delayed rectifier ... Cited by 5 - Related articles - All 4 versions
- ►jbc.org PE MacDonald, S Sewing, J Wang, JW Joseph … - Journal of Biological Chemistry, 2002 - ASBMB Voltage-dependent (Kv) outward K + currents repolarize -cell action potentials
during a glucose stimulus to limit Ca 2+ entry and insulin secretion.
Dominant-negative "knockout" of Kv2 family channels enhances ... Cited by 81 - Related articles - BL Direct - All 4 versions
- ►endojournals.org PE MacDonald, XF Ha, J Wang, SR Smukler, … - Molecular Endocrinology, 2001 - Endocrine Soc In pancreatic ß-cells, voltage-dependent K + (Kv) channels are potential
mediators of repolarization, closure of Ca 2+ channels, and limitation of
insulin secretion. The specific Kv channels expressed in ß-cells and their ... Cited by 95 - Related articles - BL Direct - All 3 versions
A Rucha, EJ Verspohl - Cell biochemistry and function, 2005 - interscience.wiley.com Heterologous desensitization is a term that describes the observation that
chronic exposure of a cell to an agonist attenuates its response to other
agonists. To characterize the cellular mechanisms that might be responsible ... Cited by 5 - Related articles - All 3 versions
GM Portela-Gomes, SM Abdel-Halim - Pancreas, 2002 - journals.lww.com Aims and Methodology: The immunocytochemical expression patterns of the
stimulatory Gs proteins (G α-s and G α-olf) and the in vitro Ca 2+ -stimulated
ACs (AC1, 3, and 8) were studied in normal and spontaneously diabetic Goto- ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►nih.gov DA Jacobson, A Kuznetsov, JP Lopez, S Kash, … - Cell metabolism, 2007 - Elsevier Voltage-gated potassium currents (Kv), primarily due to Kv2.1 channels, are
activated by glucose-stimulated pancreatic β cell depolarization, but the exact
role (or roles) of this channel in regulating insulin secretion remains ... Cited by 7 - Related articles - All 5 versions
