- ►diabetesjournals.org T Tsuboi, MA Ravier, LE Parton, GA Rutter - Diabetes, 2006 - Am Diabetes Assoc The mechanism(s) by which chronic hyperglycemia impairs glucose-stimulated
insulin secretion is poorly defined. Here, we compare the "nanomechanics" of
single exocytotic events in primary rat pancreatic ß-cells cultured for 48 ... Cited by 25 - Related articles - BL Direct - All 6 versions
GA Rutter, MK Loder, MA Ravier - Biochemical Society Transactions, 2006 - biochemsoctrans.cn Abstract Minute-to-minute control of the release of insulin by pancreatic
β-cells in response to glucose or other stimuli requires the precise delivery
of large dense-core vesicles to the plasma membrane and regulated ... Cited by 3 - Related articles - View as HTML - BL Direct - All 7 versions
A Abderrahmani, S Cheviet, M Ferdaoussi, T … - The EMBO Journal, 2006 - pubmedcentral.nih.gov The GTPases Rab3a and Rab27a and their effectors Granuphilin/Slp4 and Noc2 are
essential regulators of neuroendocrine secretion. Chronic exposure of pancreatic
β-cells to supraphysiological glucose levels decreased selectively the ... Cited by 28 - Related articles - BL Direct - All 9 versions
- ►shouxi.net CG Ostenson, H Gaisano, L Sheu, A Tibell, T … - Diabetes, 2006 - Am Diabetes Assoc Exocytosis of insulin is dependent on the soluble N-ethylmaleimide attachment
protein receptor (SNARE) complex proteins in the B-cells. We assessed insulin
release as well as gene and protein expression of SNARE complex protein in ... Cited by 49 - Related articles - BL Direct - All 5 versions
T Tsuboi, HT McMahon, GA Rutter - Journal of Biological Chemistry, 2004 - ASBMB The molecular mechanisms underlying "kiss and run" or "cavicapture" exocytosis
of dense core secretory vesicles are presently unclear. Although dynamin-1 has
previously been implicated in the recapture process in neurons, the ... Cited by 65 - Related articles - BL Direct - All 9 versions
- ►endojournals.org M Dubois, P Vacher, B Roger, D Huyghe, B … - Endocrinology, 2007 - Endocrine Soc Prolonged exposure of ß-cells to high glucose (glucotoxicity) diminishes
insulin secretion in response to glucose and has been linked to altered
generation of metabolism-secretion coupling factors. We have investigated ... Cited by 23 - Related articles - BL Direct - All 3 versions
- ►cell.com PE MacDonald, M Braun, J Galvanovskis, P … - Cell Metabolism, 2006 - Elsevier Exocytosis of secretory vesicles begins with a fusion pore connecting the
vesicle lumen to the extracellular space. This pore may then expand or it may
close to recapture the vesicle intact. The contribution of the latter, ... Cited by 21 - Related articles - All 8 versions
- ►diabetesjournals.org PE MacDonald, S Obermüller, J Vikman, J … - Diabetes, 2005 - Am Diabetes Assoc We have applied cell-attached capacitance measurements to investigate whether
synaptic-like microvesicles (SLMVs) undergo regulated exocytosis in insulinoma
and primary pancreatic β-cells. SLMV and large dense-core vesicle (LDCV) ... Cited by 33 - Related articles - All 5 versions
SG Straub, G Shanmugam, GWG Sharp - Diabetes, 2004 - Am Diabetes Assoc Electron microscopy and quantitative stereological techniques were used to study
the dynamics of the docked granule pool in the rat pancreatic β-cell. The mean
number of granules per β-cell was 11,136. After equilibration in RPMI ... Cited by 23 - Related articles - BL Direct - All 5 versions
S Speier, M Rupnik - Pflügers Archiv European Journal of Physiology, 2003 - Springer Abstract The tissue-slice technique has enabled major insights into neural and
neuroendocrine physiology. Our aim was to adapt this technique to study the
function of the endocrine pancreas. The preparation combines an in situ ... Cited by 14 - Related articles - BL Direct - All 3 versions
