- ►diabetesjournals.org B Ellger, Y Debaveye, I Vanhorebeek, L Langouche, A … - Diabetes, 2006 - Am Diabetes Assoc Tight blood glucose control with insulin reduces morbidity and mortality of critically ill
patients. However, the relative impact of maintaining normoglycemia and of glycemia-independent
actions of insulin remains unknown. We therefore independently manipulated blood ... Cited by 107 - Related articles - BL Direct - All 10 versions
B Ellger, Y Debaveye, I Vanhorebeek, L Langouche, A … - DIABETES, 2006 - Am Diabetes Assoc Tight blood glucose control with insulin reduces morbidity and mortality of critically ill
patients. However, the rela- tive impact of maintaining normoglycemia and of glycemia- independent
actions of insulin remains unknown. We therefore independently manipulated blood ... Related articles - All 2 versions
I Vanhorebeek, R De Vos, D Mesotten, PJ Wouters, C … - The Lancet, 2005 - Elsevier In the liver, hypertrophic mitochondria with an increased number of abnormal and irregular cristae
and reduced matrix electron density were observed in seven of nine conventionally treated
patients. Only one of 11 patients given intensive insulin treatment had these ... Cited by 227 - Related articles - All 13 versions
- ►nih.gov … , I Vanhorebeek, D Vlasselaers, S Vander … - Journal of Clinical …, 2005 - Am Soc Clin Investig The vascular endothelium controls vasomotor tone and microvascular flow and regulates trafficking
of nutrients and biologically active molecules. When endothelial activation is excessive, compromised
microcirculation and subsequent cellular hypoxia contribute to the risk of organ failure. ... Cited by 314 - Related articles - BL Direct - All 11 versions
- ►endojournals.org D Mesotten, JV Swinnen, F Vanderhoydonc, PJ … - Journal of Clinical …, 2004 - Endocrine Soc Compared with the conventional approach, which recommended only insulin therapy when blood
glucose levels exceeded 12 mmol/liter, strict maintenance of blood glucose levels less than 6.1
mmol/liter with intensive insulin therapy has shown to reduce intensive care mortality, ... Cited by 186 - Related articles - BL Direct - All 9 versions
- ►endojournals.org F Weekers, AP Giulietti, M Michalaki, W Coopmans, E … - Endocrinology, 2003 - Endocrine Soc Stress hyperglycemia is frequent in critically ill patients. The aim of this study was to investigate
the effect of blood glucose control with insulin on endocrine, metabolic, and immune function
in an animal model of severe injury. Seventy-two hours after alloxan injection and ... Cited by 143 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org G Van den Berghe, A Wilmer, I Milants, PJ Wouters, B … - Diabetes, 2006 - Am Diabetes Assoc Intensive insulin therapy (IIT) improves the outcome of prolonged critically ill patients, but concerns
remain regarding potential harm and the optimal blood glucose level. These questions were
addressed using the pooled dataset of two randomized controlled trials. Independent of ... Cited by 250 - Related articles - BL Direct - All 9 versions
- ►nih.gov G Van den Berghe - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Patients requiring prolonged intensive care are at high risk for multiple organ failure and
death. Insulin resistance and hyperglycemia accompany critical illness, and the severity of this
“diabetes of stress” reflects the risk of death. Recently it was shown that preventing ... Cited by 343 - Related articles - BL Direct - All 13 versions
- ►oxfordjournals.org [PDF] C Ingels, Y Debaveye, I Milants, E Buelens, A … - European heart …, 2006 - Eur Soc Cardiology Received 24 November 2005; revised 3 March 2006; accepted 9 March 2006; online
publish-ahead-of-print 11 April 2006 ... Aims To document the impact of intensive insulin therapy
during intensive care on long-term (4 years) outcome of high-risk cardiac surgery ... Cited by 92 - Related articles - BL Direct - All 5 versions
- ►critcaremed.com MPC Siroen, PAM van Leeuwen, RJ Nijveldt, T … - Critical care …, 2005 - journals.lww.com Supported, in part, by grant G.0278.03 from the Fund for Scientific Research, Flanders,
Belgium; by grant OT 03/56 from the Research Council of the Catholic University of Leuven; and
by the Belgian Foundation for Research in Congenital Heart Diseases. Greet Van den ... Cited by 83 - Related articles - All 12 versions
