- ►diabetesjournals.org A Festa, K Williams, RD'Agostino, LE Wagenknecht, … - Diabetes, 2006 - Am Diabetes Assoc Data from the UKPDS (UK Prospective Diabetes Study) indicate a continuous decline in β-cell
function in patients with type 2 diabetes. We studied longitudinal changes in β-cell function
(follow-up of 5.2 years) in subjects with normal glucose tolerance (NGT), impaired ... Cited by 76 - Related articles - BL Direct - All 5 versions
A Festa, K Williams, RD'Agostino Jr, LE Wagenknecht, … - DIABETES, 2006 - Am Diabetes Assoc I mpaired insulin secretion and impaired insulin ac- tion (increased insulin resistance) are the
two major components contributing to the pathophysiology of type 2 diabetes (1–3); their complex
relationship has been mathematically described as a curvilinear rela- tionship (4–6). ... Cited by 3 - Related articles
AH Xiang, C Wang, RK Peters, E Trigo, SL Kjos, TA … - Diabetes, 2006 - Am Diabetes Assoc The purpose of this study was to examine longitudinally the relationship among glucose
levels, pancreatic β-cell function, and insulin resistance in women at high risk for type 2
diabetes. Oral glucose tolerance tests (OGTTs) and intravenous glucose tolerance tests ( ... Cited by 33 - Related articles - BL Direct - All 5 versions
M Cnop, J Vidal, RL Hull, KM Utzschneider, DB … - Diabetes Care, 2007 - Am Diabetes Assoc RESULTS—Subjects gained weight, and their waist circumference increased (P < 0.05). Insulin
sensitivity, the acute insulin response to glucose, and glucose effectiveness did not change
significantly. However, when we accounted for the modulating effect of insulin sensitivity ... Cited by 23 - Related articles - BL Direct - All 6 versions
A Festa, K Williams, AJG Hanley, SM Haffner - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—In 1,380 individuals from the Insulin Resistance Atherosclerosis
Study, β-cell function was assessed using a frequently sampled intravenous glucose tolerance
test (first-phase insulin secretion; acute insulin response [AIR]), homeostasis model ... Cited by 8 - Related articles - All 4 versions
- ►diabetesjournals.org R Weiss, S Caprio, M Trombetta, SE Taksali, WV … - Diabetes, 2005 - Am Diabetes Assoc The profile of insulin secretion and the role of proinsulin processing across the spectrum of glucose
tolerance in obese youth have not been studied. The aims of this study were to define the role
of insulin secretion and proinsulin processing in glucose regulation in obese youth. We ... Cited by 28 - Related articles - All 4 versions
- ►diabetesjournals.org KM Utzschneider, RL Prigeon, DB Carr, RL Hull, J … - Diabetes Care, 2006 - Am Diabetes Assoc RESULTS—S i and AIR g were inversely related for the entire cohort, and this relationship was
not significantly different from hyperbolic. The inverse relationship between S i and AIR g was
not significantly different when compared between groups based on fasting glucose ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org TA Buchanan - Diabetes, 2007 - Am Diabetes Assoc In the past 6 years, several randomized controlled trials have been conducted to test the impact
of behavioral and pharmacological interventions on rates of development of type 2 diabetes
in high-risk groups (1–7). The studies have demonstrated that it is possible to reduce the ... Cited by 23 - Related articles - BL Direct - All 4 versions
N Gungor, F Bacha, R Saad, J Janosky, S Arslanian - Diabetes Care, 2005 - Am Diabetes Assoc RESULTS—Fasting glucose rate of appearance was higher in type 2 diabetic patients than in
obese control subjects (16.5 ± 1.1 vs. 12.3 ± 0.5 μmol · kg –1 · min –1 ; P = 0.002). Insulin sensitivity
was lower in type 2 diabetic patients than in obese control subjects (1.0 ± 0.1 vs. 2.0 ± 0.2 ... Cited by 42 - Related articles - All 6 versions
[CITATION] The struggle for mastery in insulin action: from triumvirate to republic
