AC Rocha-Campos, R Melki, R Zhu, N Deruytter, D … - Diabetes, 2006 - Am Diabetes Assoc Defective invariant natural killer T-cells (iNKT cells) have been implicated in the etiology of type
1 diabetes in nonobese diabetic (NOD) mice. In a genome scan of a cross between NOD and
C57BL/6 mice, the most significant locus controlling the number of iNKT cells, referred to ... Related articles - All 3 versions
AC Rocha-Campos, R Melki, R Zhu, N Deruytter, D … - DIABETES, 2006 - Am Diabetes Assoc Page 1. Original Article Genetic and Functional Analysis of the Nkt1 Locus Using
Congenic NOD Mice Improved V 14-NKT Cell Performance but Failure to Protect
Against Type 1 Diabetes Ana-Claudia Rocha-Campos, 1 Rahma ... Related articles
- ►oxfordjournals.org LM Araujo, A Puel, C Gouarin, A Hameg, JC … - International …, 2000 - Jpn Soc Immunol NKT cells are CD4 + or CD4 – CD8 – CD1d-restricted lymphocytes, characterized by the property
to rapidly produce IL-4 and IFN- in response to TCR ligation. This IL-4 burst is lacking in
autoimmunity-prone SJL and NOD strains of mice, which suggests an immunoregulatory ... Cited by 7 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org D Vallois, MC Gagnerault, P Avner, UC … - The Journal of …, 2008 - Am Assoc Immnol The number and function of immunoregulatory invariant NKT (iNKT) cells are genetically
controlled. A defect of iNKT cell ontogeny and function has been implicated as one causal factor
of NOD mouse susceptibility to type 1 diabetes. Other factors of diabetes susceptibility, ... Related articles - All 2 versions
- ►diabetesjournals.org KG Ewens, LN Johnson, B Wapelhorst, KO'Brien, S … - Diabetes, 2002 - Am Diabetes Assoc Type 1 diabetes is a complex disorder with multiple genetic loci and environmental factors contributing
to disease etiology. In the current study, a human type 1 diabetes candidate region on chromosome
1q42 was mapped at high marker density in a panel of 616 multiplex type 1 diabetic ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org F Zhang, Z Liang, N Matsuki, L Van Kaer, S … - The Journal of …, 2003 - Am Assoc Immnol Th cell differentiation is a critical event in the adaptive immune response. C57BL strains develop
predominant Th1 responses while BALB/c develops a predominant Th2 response. To identify
quantitative trait loci controlling this variation, we performed Th1/Th2 differentiation ... Cited by 16 - Related articles - BL Direct - All 4 versions
MT Fletcher, AG Baxter - Immunology and cell biology, 2009 - nature.com Type 1 natural killer T (NKT) cells are a population of CD1d-restricted, regulatory T cells that
exhibit various NK cell characteristics and rapidly produce cytokines on stimulation with glycolipid
antigen. In type I diabetes (TID), NKT cells are thought to have a tolerogenic function, ... Related articles - All 4 versions
- ►jimmunol.org N Matsuki, AK Stanic, ME Embers, L Van … - The Journal of …, 2003 - Am Assoc Immnol Nonobese diabetic (NOD) mice, a model for type I diabetes (TID), have reduced numbers of invariant
V 14J 18 TCR -chain-positive natural T (iNKT) cells that do not release IL-4 in response to in
vivo activation through their Ag receptor. The deficit in iNKT cell number and function is ... Cited by 27 - Related articles - BL Direct - All 4 versions
- ►nih.gov PT Lee, A Putnam, K Benlagha, L Teyton, … - Journal of Clinical …, 2002 - Am Soc Clin Investig Defects in IL-4–producing CD1d-autoreactive NKT cells have been implicated in numerous
Th1-mediated autoimmune diseases, including diabetes, multiple sclerosis, rheumatoid
arthritis, lupus, and systemic sclerosis. Particular attention has been focused on ... Cited by 132 - Related articles - BL Direct - All 9 versions
- ►jimmunol.org MA Jordan, JM Fletcher, D Pellicci, AG … - The Journal of …, 2007 - Am Assoc Immnol Invariant NKT cells play a critical role in controlling the strength and character of adaptive immune
responses. We have previously reported deficiencies in the numbers and function of NKT cells
in the NOD mouse strain, which is a well-validated model of type 1 diabetes and systemic ... Cited by 19 - Related articles - BL Direct - All 6 versions
