B Guigas, L Bertrand, N Taleux, M Foretz, N … - Diabetes, 2006 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) controls glucose uptake and glycolysis in muscle. Little
is known about its role in liver glucose uptake, which is controlled by glucokinase. We report
here that 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR), metformin, ... Cited by 45 - Related articles - BL Direct - All 6 versions
B Guigas, N Taleux, M Foretz, D Detaille, F … - The Biochemical …, 2007 - pubmedcentral.nih.gov AICA riboside (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) has been extensively
used in cells to activate the AMPK (AMP-activated protein kinase), a metabolic sensor involved
in cell energy homoeostasis. In the present study, we investigated the effects of AICA ... Cited by 20 - Related articles - BL Direct - All 7 versions
RL Jacobs, S Lingrell, JRB Dyck, DE Vance - Journal of Biological Chemistry, 2007 - ASBMB 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr), a commonly used indirect activator
of AMP-activated protein kinase (AMPK), inhibits phosphatidylcholine (PC) biosynthesis in freshly
isolated hepatocytes. In all nucleated mammalian cells, PC is synthesized from choline ... Cited by 21 - Related articles - All 5 versions
- ►diabetesjournals.org RR Pencek, J Shearer, RC Camacho, FD James, DB … - Diabetes, 2005 - Am Diabetes Assoc The infusion of 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) causes a rise
in tissue concentrations of the AMP analog 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranotide
(ZMP), which mimics an elevation of cellular AMP levels. The purpose of this work was to ... Cited by 25 - Related articles - All 6 versions
- ►nih.gov [PDF] MF Vincent, F Bontemps, G Van den … - Biochemical Journal, 1992 - pubmedcentral.nih.gov 5-Amino-4-imidazolecarboxamide riboside (AICAriboside; Z-riboside), the nucleotide corresponding
to AICAribotide (AICAR or ZMP), an intermediate of the 'de novo' pathway of purine nucleotide
biosynthesis, has been shown to inhibit gluconeogenesis in isolated rat hepatocytes [ ... Cited by 44 - Related articles - All 6 versions
MF Vincent, MD Erion, HE Gruber, G Van den Berghe - Diabetologia, 1996 - Springer Summary We have previously demonstrated that in isolated hepatocytes from fasted rats, AICAriboside
(5-amino 4-imidazolecarboxamide riboside), after its conversion into AICAribotide (AICAR or
ZMP), exerts a dose-dependent inhibition on fructose-l,6- bisphosphatase and hence on ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►jbc.org O Goransson, A McBride, SA Hawley, FA Ross, N … - Journal of Biological …, 2007 - ASBMB We have studied the mechanism of A-769662, a new activator of AMP-activated protein kinase
(AMPK). Unlike other pharmacological activators, it directly activates native rat AMPK by mimicking
both effects of AMP, ie allosteric activation and inhibition of dephosphorylation. We found ... Cited by 32 - Related articles - All 7 versions
- ►jlr.org S Fediuc, MP Gaidhu, RB Ceddia - The Journal of Lipid Research, 2006 - ASBMB The purpose of this study was to investigate the effects of long-chain fatty acids (LCFAs) on
AMP-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC) phosphorylation
and ß-oxidation in skeletal muscle. L6 rat skeletal muscle cells were exposed to various ... Cited by 34 - Related articles - BL Direct - All 7 versions
B Cool, B Zinker, W Chiou, L Kifle, N Cao, M Perham, R … - Cell metabolism, 2006 - Elsevier AMP-activated protein kinase (AMPK) is a key sensor and regulator of intracellular and
whole-body energy metabolism. We have identified a thienopyridone family of AMPK
activators. A-769662 directly stimulated partially purified rat liver AMPK (EC 50 = 0.8 μM) ... Cited by 91 - Related articles - All 9 versions
- ►diabetesjournals.org VA Payne, C Arden, C Wu, AJ Lange, L Agius - Diabetes, 2005 - Am Diabetes Assoc Hepatic glucokinase is regulated by a 68-kDa regulatory protein (GKRP) that is both an inhibitor
and nuclear receptor for glucokinase. We tested the role of 6-phosphofructo-2-kinase/fructose
-2,6-bisphosphatase (PFK2) in regulating glucokinase compartmentation in hepatocytes. ... Cited by 29 - Related articles - All 5 versions
